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MyopathyAka: Myositis

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  1. See Also
    1. Myopathy Causes
    2. Acute Motor Weakness Causes
    3. Muscular Dystrophy
  2. Findings
    1. Suggestive of myopathy
      1. Gradual onset of symmetric weakness
      2. Proximal weakness
        1. Difficulty combing hair
        2. Difficulty walking up stairs
      3. Neck Flexion weaker than neck extension
      4. Deep Tendon Reflexes preserved
    2. Suggestive of alternative diagnosis (i.e. Neuropathy)
      1. Sudden onset of asymmetric weakness
      2. Paresthesias in extremities
      3. Bowel dysfunction (e.g. stool Incontinence)
      4. Bladder dysfunction (e.g. Urinary Incontinence)
      5. Distal weakness suggests Neuropathy
        1. Except in Guillain-Barre, Myotonic Dystrophy
      6. Deep Tendon Reflexes lost
  3. History: Direct to specific Myopathy
    1. Family History of myopathy: Muscular Dystrophy
    2. Difficult swallowing: Polymyositis
    3. Weakness varies and includes eyes: Myasthenia Gravis
    4. Age of onset
      1. Age <30: Muscular Dystrophy
  4. Labs
    1. Creatine Phosphokinase (CPK) increased
    2. Aspartate Aminotransferase (AST) may be increased
    3. Aldolase may be increased
    4. Lactate Dehydrogenase (LDH) may be increased
  5. Diagnostics
    1. Electromyogram (EMG)
    2. Nerve Conduction Studies (NCS)
    3. Muscle biopsy
  6. Causes
    1. See Myopathy Causes
    2. See Medication Causes of Myositis
    3. See Muscular Dystrophy
    4. See Acute Motor Weakness Causes
      1. Critical to rule-out emergent causes
    5. List of some treatable myopathies
      1. Thyroid Myopathy (Hypothyroidism, Hyperthyroidism)
      2. Steroid Myopathy
      3. Polymyositis
      4. Alcoholic myopathy
      5. Periodic paralysis
      6. Polymyalgia Rheumatica
      7. Myasthenia Gravis
      8. Eaton-Lambert Syndrome

Myositis (C0027121)

Definition (MSH)Inflammation of skeletal muscle (MUSCLE, SKELETAL). Infectious, autoimmune, and paraneoplastic processes represent some of the more common conditions that may be associated with myositis. (From Adams et al., Principles of Neurology, 6th ed., pp 1402-13)
Definition (CSP)inflammation of skeletal muscle.
ConceptsDisease or Syndrome (T047)
EnglishIIM, INFLAMM MUSCLE DIS, INFLAMM MYOPATHY, Inflammatory disorder of muscle, Inflammatory Muscle Disease, Inflammatory Muscle Diseases, Inflammatory Myopathies, Inflammatory Myopathy, MUSCLE DIS INFLAMM, Muscle inflammation, MYOPATHY INFLAMM, Myositides, Myositis, Myositis unspecified
Spanishmiopatia inflamatoria, miositis, trastorno muscular inflamatorio
Parent ConceptsRheumatism (C0035435), Myopathy (C0026848), MYOSITIC DISORDERS (C0549655), Non-Neoplastic Soft Tissue Disorder (C1335043), Myositis (C0027121), Inflammation of specific body organs (C1285331), Inflammation of specific body structures or tissue (C1285332), Inflammatory disorder of musculoskeletal system (C1285339), Disorder of skeletal muscle (C1533847)
SourcesAOD, COSTAR, CSP, CST, DXP, LCH, MEDLINEPLUS, MSH, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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