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Aspartate AminotransferaseAka: Serum Glutamic Oxaloacetic Transaminase, Glutamic oxaloacetic transaminase, Serum AST, AST, SGOT
- See Also
- Definition
- Serum transaminase marker of hepatocyte injury
- Less specific than ALT (present outside liver)
- Normal
- Level: <35 U/L
- Increased
- See Liver Function Test Abnormality
- Sensitive marker for hepatocellular marker
- Same causes as Alanine Aminotransferase (ALT)
- AST is less specific then ALT (present outside liver)
- Heart, lung, kidney, brain, pancreas, muscle
- White Blood Cells and Red Blood Cells
- Liver disease causes of increased AST
- See Alanine Aminotransferase (ALT)
- Non-liver disease causes of increased AST
- Myocardial Infarction
- Myocarditis
- Renal Infarction
- Pulmonary infarction
- Severe muscle trauma
- Dermatomyositis
- Polymyositis
- Malignancy
- Seizure disorder
- Hyperthyroidism
- Celiac Sprue
- Hemolysis
- Conditions with ratio of ALT to AST > 2
- Alcoholism
- Wilson's Disease (ratio may exceed 4)
Aspartate Transaminase (C0004002) | |
|---|---|
| Definition (MSH) | Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) |
| MSH | D001219 |
| English | ASAT - Aspartate aminotransferase, Aspartate Aminotransferase, Aspartate Aminotransferases, Aspartate Apoaminotransferase, Aspartate Transaminase, AST, AST - Aspartate transaminase, Glutamate Aspartate Transaminase, Glutamate oxaloacetate transaminase, Glutamate-Aspartate Transaminase, glutamic aspartic transaminase, GLUTAMIC OXALOACETIC TRANS 000, Glutamic Oxaloacetic Transaminase, Glutamic-aspartic transaminase, Glutamic-Oxaloacetic Transaminase, GOT, L Aspartate 2 Oxoglutarate Aminotransferase, L-Aspartate-2-Oxoglutarate Aminotransferase, S-ASAT, Transaminase A |
| Spanish | aspartato aminotransferasa, transaminasa A, transaminasa glutamica - aspartica, transaminasa glutamica - oxaloacetica |
| Parent Concepts | Transaminases (C0002594), Cardiac enzymes (C0443763), Liver enzyme (C0443764) |
| Sources | AOD, CSP, LNC, MSH, MTH, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
SGOT - Glutamate oxaloacetate transaminase (C0242192) | |
|---|---|
| Definition (NCI) | Activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. (NCI) |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) |
| MSH | D001219 |
| English | AST, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic-Oxaloacetic Transaminase, SGOT, SGOT - Glutamate oxaloacetate transaminase |
| Parent Concepts | Transaminases (C0002594) |
| Sources | MSH, MTH, NCI, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
