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Aspartate AminotransferaseAka: Serum Glutamic Oxaloacetic Transaminase, Glutamic oxaloacetic transaminase, Serum AST, AST, SGOT

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  1. See Also
    1. Alanine Aminotransferase
    2. Liver Function Test Abnormality
    3. Liver Function Test
  2. Definition
    1. Serum transaminase marker of hepatocyte injury
    2. Less specific than ALT (present outside liver)
  3. Normal
    1. Level: <35 U/L
  4. Increased
    1. See Liver Function Test Abnormality
    2. Sensitive marker for hepatocellular marker
      1. Same causes as Alanine Aminotransferase (ALT)
    3. AST is less specific then ALT (present outside liver)
      1. Heart, lung, kidney, brain, pancreas, muscle
      2. White Blood Cells and Red Blood Cells
    4. Liver disease causes of increased AST
      1. See Alanine Aminotransferase (ALT)
    5. Non-liver disease causes of increased AST
      1. Myocardial Infarction
      2. Myocarditis
      3. Renal Infarction
      4. Pulmonary infarction
      5. Severe muscle trauma
      6. Dermatomyositis
      7. Polymyositis
      8. Malignancy
      9. Seizure disorder
      10. Hyperthyroidism
      11. Celiac Sprue
      12. Hemolysis
    6. Conditions with ratio of ALT to AST > 2
      1. Alcoholism
      2. Wilson's Disease (ratio may exceed 4)

Aspartate Transaminase (C0004002)

Definition (MSH)Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
EnglishAspartate Aminotransferase, Aspartate Aminotransferases, Aspartate Apoaminotransferase, Aspartate Transaminase, AST, Glutamate Aspartate Transaminase, Glutamate oxaloacetate transaminase, glutamic aspartic transaminase, GLUTAMIC OXALOACETIC TRANS 000, Glutamic Oxaloacetic Transaminase, GOT, L Aspartate 2 Oxoglutarate Aminotransferase, Transaminase A
Spanishaspartato aminotransferasa, transaminasa A
CreditsDerived from the NIH UMLS (Unified Medical Language System)


SGOT - Glutamate oxaloacetate transaminase (C0242192)

Definition (NCI)Activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. (NCI)
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
EnglishAST, Serum Glutamic Oxaloacetic Transaminase, SGOT
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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