Rheumatology Book

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Polymyositis

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  1. See Also
    1. Dermatomyositis
  2. Types
    1. Type 1: Primary Idiopathic Polymyositis (33%)
    2. Type 2: Primary Idiopathic Dermatomyositis (25%)
    3. Type 3: Neoplasia related
    4. Type 4: Childhood disease with Vasculitis
    5. Type 5: Collagen Vascular disease related
    6. Type 6: Miscellaneous (Inclusion body, Eosinophilic)
  3. Diagnostic Criteria
    1. Dermatomyositis Diagnosis
      1. Four or more findings seen in Polymyositis (below)
      2. Cutaneous findings suggestive of Dermatomyositis
    2. Polymyositis Diagnosis (4 or more criteria below)
      1. Proximal Muscle Weakness (trunk, thighs, shoulders)
      2. Increased serum Creatine Phosphokinase or Aldolase
      3. Muscle pain on grasping or spontaneously
      4. EMG myogenic changes (see Polymyositis Evaluation)
      5. Positive anti-Jo1 Antibody
      6. Nondestructive arthritis or arthralgia
      7. Pathologic inflammatory signs
      8. Systemic inflammation signs
        1. Temperature over 37 C at axilla
        2. C-Reactive Protein increased
        3. Erythrocyte Sedimentation Rate >20 mm/hour
  4. Differential Diagnosis
    1. See Polymyositis Differential Diagnosis
  5. Evaluation
    1. See Polymyositis Evaluation
  6. Management
    1. See Polymyositis Management
  7. References
    1. Koler (2001) Am Fam Physician 64(9):1565
    2. Pachman (1995) Pediatr Clin North Am 42:1071
    3. Tanimoto (1995) J Rheumatol 22:4

Polymyositis (C0085655)

Definition (MSH)Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Definition (CSP)inflammation of a number of voluntary muscles simultaneously.
ConceptsDisease or Syndrome (T047)
ICD9710.4
MSHD017285
EnglishMultiple Myositis, Neuromyositis, Neuromyositis-retired, PM - Polymyositis, Polymyositides, Polymyositis
Spanishneuromiositis - RETIRADO -, polimiositis
Parent ConceptsMyalgias/Myopathy (C0221570), Connective Tissue Diseases (C0009782), Myositis (C0027121), Diffuse disease of connective tissue (C0041785), Reason not stated concept (C1276325), Duplicate concept (C1274013)
SourcesAIR, AOD, COSTAR, CSP, CST, DXP, ICD9CM, MEDLINEPLUS, MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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