Gastroenterology Book

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LDHAka: Lactate Dehydrogenase, Lactic Dehydrogenase

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  1. See Also
    1. Liver Function Test
    2. Liver Function Test Abnormality
  2. Definition
    1. Least specific marker of hepatocyte injury
  3. Normal Total LDH
    1. Range: 300-600 U/L (varies widely per lab)
  4. Increased Total LDH
    1. Myocardial Infarction
    2. Lung Infarction
    3. Kidney infarction
    4. Cerebrovascular Accident
    5. Cardiopulmonary disease
    6. Liver disease (non-specific)
      1. Dramatically increased in ischemic hepatitis
      2. Increased with alk phos in liver metastases
    7. Collagen-vascular disease
    8. Hemolytic Anemia
    9. Megaloblastic Anemia
    10. Transfusions
    11. Acute Pancreatitis
    12. Intestinal Obstruction
    13. Muscle trauma
    14. Hypotension or shock
    15. Epstein Barr Virus (EBV)
    16. Cytomegalovirus (CMV)
    17. Neoplasm
    18. Hypothyroidism

Lactate Dehydrogenase (C0022917)

Definition (CSP)do not confuse with EC 1.1.2.3, EC 1.1.2.4, or EC 1.1.2.5, lactate dehydrogenase (cytochrome).
Definition (MSH)A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Definition (NCI)A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
EnglishEC 1.1.1.27, L lactate dehydrogenase, Lactate Dehydrogenase, LACTATE DEHYDROGENASE L, lactate dehydrogenases, Lactic acid dehydrogenase, LDH
Spanishácido láctico deshidrogenasa, acido lactico deshidrogenasa, láctico deshidrogenasa, lactato deshidrogenasa, lactico deshidrogenasa, LDH
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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