Gastroenterology Book

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ProchlorperazineAka: Compazine

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  1. Indications
    1. Nausea or Vomiting
    2. Migraine Headache
    3. Motion Sickness
    4. Vertigo
    5. Hiccups
  2. Mechanism
    1. Phenothiazine Antiemetic
    2. Dopamine 2 Antagonist
  3. Adverse effects
    1. Orthostatic Hypotension
    2. Extrapyramidal Reaction
      1. Reactions
        1. Akathisia (25-60% after single dose)
        2. Dystonic Reaction (4% after a single dose)
      2. Concurrent Benadryl 50 mg IV prevents Akathisia
        1. Vinson (2001) Ann Emerg Med 37(2):125
  4. Dosing
    1. Adults
      1. Compazine 5-10 mg PO/IV/IM q6-8 hours
      2. Compazine 25 mg PR q12 hours
      3. Sustained release Compazine 15 mg PO qam or 10 mg bid
    2. Children (over age 2 years or >10 kg)
      1. Compazine 0.1 mg/kg/dose PO/PR q6-8 hours
      2. Compazine 0.1 to 0.15 mg IM q6-8 hours
  5. Precautions
    1. IV dosing must be administered over 2 minutes or more
    2. Lowers Seizure threshold
  6. Efficacy
    1. Better Antiemetic than Phenergan in ER patients
      1. Ernst (2000) Ann Emerg Med 36(2):89
  7. References
    1. Johnson (1993) Harriet Lane, Mosby, p. 521
    2. (2002) Tarascon Pocket Pharmacopoeia, p. 67
    3. Olsen (2000) Am J Emerg Med 18(5):609
    4. Vinson (2001) Ann Emerg Med 37(2):125

Prochlorperazine (C0033229)

Definition (MSH)A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Definition (CSP)phenothiazine derivative used chiefly as an antiemetic.
Definition (NCI)(pro-klor-PAIR-a-zeen) A drug that prevents or reduces nausea and vomiting. It belongs to the family of drugs called antiemetics.
Definition (PDQ)A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C774" NCI Thesaurus)
Definition (NCI)A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD011346
EnglishPCPZ, Prochlorperazine, PROCHLORPERAZINE PREPARATION, RP 6140, SKF-4657
Spanishproclorperacina, proclorperazina
Parent ConceptsPhenothiazines (C0031436), Antiemetics (C0003297), Antipsychotic Agents (C0040615), Prochlorperazine (C0033229), Propylpiperazine derivative of phenothiazine (C0304377), Antiemetics (Non-5-HT3 Antagonists) (C1579363)
SourcesAOD, CSP, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Compazine (C0701017)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD011346
EnglishCompazine
Spanishcompacina, compazina
SourcesLNC, MSH, NCI, PDQ, RXNORM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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