III. Mechanism

IV. Adverse effects

  1. Orthostatic Hypotension
  2. Extrapyramidal Reaction
    1. Precaution
      1. Reactions may be delayed up to 2 weeks after dose
    2. Reactions
      1. Akathisia (25-60% after single dose)
      2. Dystonic Reaction (4% after a single dose)
      3. Olsen (2000) Am J Emerg Med 18(5): 609-11 +PMID:10999579 [PubMed]
      4. Drotts (1999) Ann Emerg Med 34(4 Pt 1): 469-75 [PubMed]
    3. Concurrent Diphenhydramine (Benadryl) prevents Akathisia (NNT 5, ARR 22%)
      1. Diphenhydramine (Benadryl) 50 mg IV (adults) was the dose used in study
      2. Vinson (2001) Ann Emerg Med 37(2):125-31 +PMID:11174228 [PubMed]

V. Dosing

  1. Adults
    1. Compazine 5-10 mg PO/IV/IM q6-8 hours
    2. Compazine 25 mg PR q12 hours
    3. Sustained release Compazine 15 mg PO qam or 10 mg bid
  2. Children (over age 2 years or >10 kg)
    1. Compazine 0.1 mg/kg/dose PO/PR q6-8 hours
    2. Compazine 0.1 to 0.15 mg IM q6-8 hours

VI. Precautions

  1. IV dosing must be administered over 2 minutes or more
  2. Lowers Seizure threshold

VIII. References

  1. Johnson (1993) Harriet Lane, Mosby, p. 521
  2. (2002) Tarascon Pocket Pharmacopoeia, p. 67
  3. Olsen (2000) Am J Emerg Med 18(5):609-11 [PubMed]
  4. Vinson (2001) Ann Emerg Med 37(2):125-31 [PubMed]

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Cost: Medications

Prochlorperazine (on 6/18/2017 at Walmart.com)
Prochlorperazine 10mg #30 tablets for $4.00 $0.13 each
Prochlorperazine 10mg #90 tablets for $10.00 $0.11 each
prochlorperazine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PROCHLORPERAZINE 10 MG TAB Generic $0.09 each
PROCHLORPERAZINE 25 MG SUPP Generic $7.40 each
PROCHLORPERAZINE 5 MG TABLET Generic $0.07 each

Ontology: Prochlorperazine (C0033229)

Definition (NCI) A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)
Definition (NCI_NCI-GLOSS) A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics.
Definition (MSH) A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Definition (CSP) phenothiazine derivative used chiefly as an antiemetic.
Definition (PDQ) A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C774" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011346
SnomedCT 322128008, 321493000, 372853006, 79129001
LNC LP102316-9, MTHU036745
English Prochlorperazine, 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, Prochlorperazine [antipsych], Prochlorperazine [antipsych] [see dhe..], Prochlorperazine [nausea], 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine, prochlorperazine (medication), PROCHLORPERAZINE, Prochlorperazine [Chemical/Ingredient], Prochlorperazine [nausea] (product), Prochlorperazine [antipsych] [see dhe..] (product), prochlorperazine, Prochlorperazine (product), Prochlorperazine (substance), PCPZ, Prochlorperazine [antipsych] [see dhe..] (substance), Prochlorperazine [nausea] (substance)
Swedish Proklorperazin
Czech prochlorperazin
Finnish Proklooriperatsiini
Russian PROKHLORPERAZIN, ПРОХЛОРПЕРАЗИН
Japanese プロクロルペラジン
Spanish proclorperacina (producto), proclorperazina, proclorperazina (producto), proclorperazina [antipsicótico] [véase dhe...], proclorperazina [náuseas], proclorperazina [antipsicótico] [véase dhe...] (producto), proclorperazina [náuseas] (producto), proclorperacina (sustancia), proclorperacina, Proclorperazina
Polish Prochlorperazyna
French Prochlorpérazine
German Prochlorperazin
Italian Procloroperazina
Portuguese Proclorperazina

Ontology: Compazine (C0701017)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011346
SnomedCT 79129001
Spanish compazina, compacina
English compazine, Compazine