Gastroenterology Book

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Promethazine

Aka: Promethazine, Phenergan
  1. Indications
    1. Nausea or Vomiting
    2. Motion Sickness or Vertigo
      1. Other agents are preferred (e.g. Dimenhydrinate)
  2. Mechanism
    1. Phenothiazine Antiemetic
  3. Contraindications
    1. Do not use under age 2 years
  4. Adverse Effects
    1. Excessive Sedation
    2. Respiratory Depression
      1. Apnea and death have occurred in children
  5. Precautions
    1. Long plasma half-life (observe prior to discharge)
    2. Lowers Seizure threshold
    3. Avoid use in children (absolutely contraindicated <2yo)
  6. Dosing (IV dosing used but not FDA labeled)
    1. Adults: 12.5 to 25 mg PO/IM/PR q4-6 hours
    2. Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours
      1. Maximum: 25 mg per dose
  7. Efficacy
    1. Less effective Antiemetic than Phenergan in ER patients
      1. Ernst (2000) Ann Emerg Med 36(2): 89-94
    2. Sedation may delay Emergency Room discharge
  8. References
    1. Johnson (1993) Harriet Lane, Mosby, p. 521
    2. (2002) Tarascon Pocket Pharmacopoeia, p. 67

Promethazine (C0033405)

Definition (CHV) a drug used to treat allergy symptoms
Definition (CHV) a drug used to treat allergy symptoms
Definition (MSH) A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Definition (NCI) A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011398
SnomedCT 322154000, 256051006, 372871004, 8372007
English Promethazine, promethazine, 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, Promethazine [nausea], Promethazine [nausea] [see c8i..], Promethazine [nausea] [see c8i..] (product), Proazamine, Prometazin, Promethazine [Chemical/Ingredient], prometazin, Diprazinum, Promethazine product, Promethazine (product), Promethazine (substance), Promethazine [dup] (substance), Promethazine [nausea] [see c8i..] (substance), PROMETHAZINE
Swedish Prometazin
Czech promethazin
Spanish Promethazine [dup] (substance), Promethazine, prometazina [náuseas] [ver c8i..], prometazina [náuseas] [ver c8i..] (producto), prometazina (sustancia), prometacina (sustancia), prometacina, prometazina (producto), prometazina, Fenergan, Proazamina, Prometazina
Finnish Prometatsiini
Russian PROZAMIN, PROMETAZIN, TIAZINAMII, METILPROMETAZIN, МЕТИЛПРОМЕТАЗИН, ПРОЗАМИН, ПРОМЕТАЗИН, ТИАЗИНАМИЙ
Japanese ヒベルナ, メチレンジサルチル酸プロメタジン, プロザミン, プロメタジン塩酸塩, ピレチア, フェネルガン, 塩酸プロメタジン, イソプロメタジン, プロメタジン
Polish Prometazyna, Difergan, Fenergan
French Prométhazine
German Proazamin, Promethazin
Italian Prometazina
Portuguese Fenergan, Proazamina, Prometazina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Phenergan (C0591971)

Definition (CHV) brand name of an allergy medicine
Definition (CHV) brand name of an allergy medicine
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011398
English Phenargan, phenergan, phenergan [brand name], Phenergan
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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