II. Mechanism

III. Disadvantages

  1. Weak effect
  2. Expensive
  3. May worsen resistance for better drugs

IV. Adverse Effects

  1. Rash
  2. Prolonged QT Interval
  3. Hyperprolactinemia (rare)

V. Drug Interactions

  1. Garlic supplements (do not use with Saquinavir)
    1. Reduces Saquinavir concentrations by 50%
    2. Levels may remain reduced even after stopiing Garlic
    3. Piscitelli (2002) Clin Infect Dis 34:234-8 [PubMed]

VI. Dosing

  1. Saquinavir 600 mg PO tid ($572/month)
  2. If taken without food, may have no antiviral activity
    1. Take within 2 hours after a full meal
    2. Meals increase absorption and decrease GI upset

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Cost: Medications

invirase (on 1/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
INVIRASE 500 MG TABLET $9.29 each

Ontology: Saquinavir (C0286738)

Definition (NCI) A peptidomimetic inhibitor of human immunodeficiency virus (HIV) protease.
Definition (MSH) An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.
Definition (CSP) HIV protease inhibitor which acts as an analog of an HIV protease cleavage site.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D019258
SnomedCT 108700005, 372530001
LNC LP14466-4, MTHU008513
English Saquinavir, Saquinivir, saquinavir (medication), Saquinavir [Chemical/Ingredient], saquinivir, SQV, saquinavir, SAQUINAVIR, Saquinavir product, Saquinavir (product), Saquinavir (substance)
Czech saquinavir
Finnish Sakinaviiri
Russian SAKHINAVIR, САХИНАВИР
Japanese サキナビル
Swedish Sakvinavir
Italian Saquinivir, Saquinavir
Polish Sakwinawir
Spanish saquinavir (producto), saquinavir (sustancia), saquinavir, Saquinavir
French Saquinavir
German Saquinavir
Portuguese Saquinavir

Ontology: Invirase (C0701215)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D019258
English invirase, Invirase