II. Indications

  1. Solid Organ Transplant Immunosuppression (maintenance prevention of rejection)

III. Preparations

  1. Sirolimus
  2. Everolimus

IV. Adverse Effects

  1. Hyperlipidemia
  2. Hepatic artery thrombosis
  3. Myelosuppression
  4. Pulmonary fibrosis
  5. Rash
  6. Delayed Wound Healing

V. Drug Interactions

  1. See Cytochrome P-450 3A4
  2. Agents that increase Purine Synthesis Inhibitor concentrations
    1. Linezolid potentiates myelosuppression
    2. Erythromycin (and Clarithromycin to a lesser extent)
  3. Agents that decrease Purine Synthesis Inhibitor concentrations
    1. Rifampin

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Related Studies

Cost: Medications

sirolimus (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SIROLIMUS 0.5 MG TABLET Generic $5.11 each
SIROLIMUS 1 MG TABLET Generic $4.36 each
SIROLIMUS 1 MG/ML SOLUTION Generic $8.60 per ml
SIROLIMUS 2 MG TABLET Generic $3.81 each
everolimus (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
EVEROLIMUS 0.5 MG TABLET Generic $12.55 each