II. Indications

  1. Uses with good supporting evidence
    1. Morning Sickness or Hyperemesis Gravidarum
    2. Postoperative Nausea or Vomiting
  2. Uses with variable evidence to support
    1. Motion Sickness
    2. Osteoartthritis
    3. Chemotherapy-Induced Nausea

III. Precautions: Pregnancy (mixed safety results)

  1. If used in pregnancy, then use with caution
  2. Ginger affects testosterone binding
  3. Ginger affects thromboxane synthetase activity
  4. Animal studies showed increased Embryo loss
  5. Larimore (2000) Prim Care 27(1): 35-53 [PubMed]

IV. Efficacy: Ginger appears effective in Morning Sickness

  1. Effective, safe and well tolerated
    1. Smith (2004) Obstet Gynecol 103:639-45 [PubMed]
  2. Dose of 250 mg qid showed benefit in 70% of cases
    1. Vutyavanich (2001) Obstet Gynecol 97:577-82 [PubMed]

V. Drug Interactions

  1. Warfarin (Coumadin) - possible interaction

VI. Adverse Effects

  1. Mild gastrointestinal upset (e.g. Reflux or Diarrhea)

VII. Dosing

  1. General range: 250 to 1000 mg PO daily to qid
  2. Pregnancy-induced Nausea: 250 mg PO four times daily

VIII. Cost

  1. Inexpensive (<$20 per month)

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Ontology: Ginger extract (C0939895)

Definition (NCI) An extract of the rhizome of the perennial plant Zingiber officinale with potential antineoplastic activity. Ginger extract contains a number of different phenolic compounds, some of which have displayed antineoplastic, anti-inflammatory, and antioxidant activities. This agent also exhibits antiemetic properties.
Definition (PDQ) A rhizome herb isolated from the plant Zingiber officinale with potential antineoplastic activity. Ginger contains a number of different phenolic compounds, some of which have displayed antineoplastic, anti-inflammatory, and antioxidant activities. This agent also exhibits antiemetic properties. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38711&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38711&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2691" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Ginger Extract, ginger (medication), gingers, ginger extract, extract ginger, ginger, Ginger, Ginger extract, GINGER