II. Indication

  1. Scabies (refractory to Permethrin 5%)
  2. Head Lice
  3. Strongyloidiasis
  4. Onchocerciasis

III. Mechanism

  1. Related to Macrolide antibiotics
  2. Developed initially as veterinary anti-parasitic agent

IV. Preparations

  1. Ivermectin 6 mg tablet

V. Dosing

  1. Scabies or Head Lice
    1. Ivermectin 200 mcg/kg PO x1 dose, repeat in 10 days
  2. Strongyloidiasis
    1. Ivermectin 200 mcg/kg PO for 1 dose
  3. Onchocerciasis
    1. Ivermectin 150 mcg/kg PO for 1 dose

VI. Efficacy: Scabies

VII. Precautions

  1. Safe in children >15 kg (33 pounds)
  2. Avoid in Lactation
  3. Pregnancy Category: C

VIII. Adverse Effects (due to allergy to parasite death)

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Cost: Medications

ivermectin (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
IVERMECTIN 3 MG TABLET Generic $4.05 each
stromectol (on 12/23/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
STROMECTOL 3 MG TABLET Generic $4.05 each

Ontology: Ivermectin (C0022322)

Definition (NCI) A macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. Distinct from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly. As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby resulting in paralysis and death of the parasites. Ivermectin does not readily pass the mammal blood-brain barrier to the central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of this agent.
Definition (MSH) A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007559
SnomedCT 387559003, 96138006
English Ivermectin, ivermectin, ivermectin (medication), IVERMECTIN, Ivermectin [Chemical/Ingredient], Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-, Ivermectin (product), Ivermectin (substance)
Swedish Ivermektin
Czech ivermektin
Finnish Ivermektiini
Russian IVERMEKTIN, ИВЕРМЕКТИН
Japanese イベルメクチン
Polish Iwermektyna, Ivermectin
Spanish ivermectina (producto), ivermectina (sustancia), ivermectina, Ivermectina
French Ivermectine
German Ivermectin
Italian Ivermectina
Portuguese Ivermectina

Ontology: Stromectol (C0723477)

Definition (MSH) Oral preparation of ivermectin.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007559
English Stromectol, Ivermectin Merck Brand, Merck Brand of Ivermectin

Ontology: Mectizan (C0751253)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007559
English Mectizan