Chlorambucil

Aka: Chlorambucil, Leukeran

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II. Indications

  1. FDA-Approved
    1. Chronic Lymphocytic Leukemia (CLL)
    2. Lymphoma
  2. Off-Label
    1. Behcet's Disease (Meningoencephalitis, Uveitis)
    2. Membranous Nephropathy
    3. Ovarian Cancer

III. Mechanism

  1. See Alkylating Agent
  2. Antineoplastic aromatic nitrogen mustard
    1. As with other Alkylating Agents (and nitrogen mustards), cross-links DNA

IV. Medications

  1. Chlorambucil Tablets (Leukeran): 2 mg

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Alopecia
  2. Bone Marrow Suppression
  3. Impaired future fertility
  4. Secondary Malignancy
  5. Seizures

VII. Safety

  1. Avoid in Lactation
  2. Pregnancy Category D (avoid)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count

VIII. Drug Interactions

  1. Live Vaccines
    1. Avoid while on Chlorambucil

IX. Resources

  1. Chlorambucil Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e3d7a0f9-d704-4676-b16e-622ff6d22aa2

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