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Brugada SyndromeAka: Sudden Arrhythmia Death Syndrome, SADS, Bangungut, Pokkuri, Lai Tai, Sleep Death
- See Also
- Arrhythmias in Athletes
- Sudden Death in Athletes
- Sudden Arrhythmia Death Syndrome (Brugada Syndrome)
- Definition
- Sudden unexpected nocturnal death
- Includes only idiopathic cases of Sudden Cardiac Death
- Epidemiology
- Incidence: Uncommon
- Accounts for <5% of Sudden Cardiac Death cases
- Family History of sudden death events often present
- Most common in men
- Greater Incidence in Southeast asia
- Northeastern Thailand (40/year per 100,000)
- Japan
- Philipines
- Incidence: Uncommon
- Pathophysiology
- Inherited disorder of myocardial sodium channels
- Associated EKG findings
- Prolonged QT Interval
- Brugada Sign
- Seen best in the right precordial leads (V1-V3)
- End of QRS marked by significant upward deflection
- ST segment elevation
- Associated with Right Bundle Branch Block
- Symptoms
- Often asymptomatic until terminal event (40%)
- Exertional Syncope history may be present
- References
Brugada Syndrome (C1142166) | |
|---|---|
| Definition (MSH) | An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK, high risk of VENTRICULAR TACHYCARDIA or VENTRICULAR FIBRILLATION, SYNCOPAL EPISODE, and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D053840 |
| English | Brugada Syndrome, SUDDEN UNEXPLAINED NOCTURNAL DEATH SYNDROME, SUNDS |
| Spanish | sindrome de Brugada |
| Parent Concepts | cardiac arrhythmia (C0003811), Genetic Diseases, Inborn (C0950123), Conduction disorder of the heart (C0264886) |
| Sources | MSH, OMIM, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
