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MarijuanaAka: Hashish, Cannabis, THC

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  1. See Also
    1. Chemical Dependency
    2. Substance Abuse Evaluation
  2. Class
    1. Relaxant, Euphoriant, and Hallucinogen (high doses)
    2. Schedule I
  3. Pharmacokinetics
    1. THC (5-20 mg): 2-4 hour duration
    2. Long half life
  4. Street Names
    1. Pot
    2. Grass
    3. Tea
    4. Dagga
    5. Kif
    6. Joint
    7. Reefer
    8. Weed
    9. Dope
  5. Background
    1. Derived naturally from hemp, Cannabis sativa
    2. Smoked or eaten (e.g. "Hash Brownies")
  6. Pathophysiology
    1. Similar to highly addictive "hard" drugs or Opioids
      1. Results in Dopamine release
      2. Blocked by Naloxone
    2. Marijuana considered a gateway drug
      1. Use leads to Opiate Abuse
    3. References
      1. Tanda (1997) Science 276:2048
  7. Symptoms
    1. Acute Effects
      1. Euphoria
      2. Relaxed inhibitions
      3. Increased appetite
      4. Disoriented behavior
    2. Chronic Use: Amotivational syndrome
      1. Aimless
      2. Uncommunicative
  8. Withdrawal Symptoms
    1. Anorexia
    2. Insomnia
    3. Anxiety
    4. Depression
  9. Symptoms or Signs of Toxicity
    1. Dysphoria
    2. Tachycardia
    3. Orthostatic Hypotension
    4. May precipitate latent Schizophrenia
  10. Toxicity Management
    1. Usually no specific treatment needed
    2. Benzodiazepines for severe reactions

Hashish (C0018613)

ConceptsSubstance (T167)
EnglishCannabis resin - non-pharmaceutical, Hashish, Marihuana resin, Marijuana resin
Spanishresina de Cannabis - uso no farmaceutico
Parent ConceptsCannabis substance (C0678449), Psychoactive substance of abuse - non-pharmaceutical (C0443078)
SourcesAOD, CSP, MSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Marihuana (C0024808)

Definition (PDQ)Any part of, or extract from, the female hemp plant Cannabis sativa. Marijuana contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive properties. This agent has potential use for treating cancer pain and cachexia. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269131&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269131&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26659" NCI Thesaurus)
Definition (NCI)Any part of, or extract from, the female hemp plant Cannabis sativa. Marijuana contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive properties. This agent has potential use for treating cancer pain and cachexia. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishCanabis, cannabinols in any form, cannabis, Marihuana, Marijuana, marijuana in any form
Spanishmarihuana
Parent ConceptsAOD substance or product (C0678374), Opioids (C0242402), Adjuvant Analgesic (C1510809), Opioid Receptor Agonist (C1883695)
SourcesAOD, MSH, MTH, NCI, PDQ, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Tetrahydrocannabinol (C0039663)

Definition (MSH)A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC.
Definition (NCI)A synthetic pill form of delta-9-tetrahydrocannabinol (THC), an active ingredient in marijuana that is used to treat nausea and vomiting associated with cancer chemotherapy.
Definition (PDQ)A synthetic form of delta-9-tetrahydrocannabinol, a psychoactive substance found in Cannabis sativa. Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39707&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39707&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C867" NCI Thesaurus)
Definition (NCI)A synthetic form of delta-9-tetrahydrocannabinol, a psychoactive substance found in Cannabis sativa. Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
English9 ene Tetrahydrocannabinol, 9-ene-Tetrahydrocannabinol, delta 9-tetrahydrocannabinol, DELTA THC 09, delta-9-Tetrahydrocannabinol, Dronabinol, DRONABINOL PREPARATION, Synthetic delta-9-Tetrahydrocannabinol, Tetrahydrocannabinol, THC
Spanishdelta-9-tetrahidrocanabinol, delta-9-tetrahidrocanabinol sintetico, delta-9-tetrahidrocannabinol, dronabinol, tetrahidrocanabinol
Parent ConceptsTetrahydrocannabinol (C0039663), cannabinoid of abuse (C0678448), Cannabinoids (C0006864), Antiemetics (C0003297), Marijuana derivative (C0304395), Duplicate concept (C1274013), Synthetic cannabinoid receptor agonist (C1720260), Antiemetics (Non-5-HT3 Antagonists) (C1579363)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Cannabis (C0936079)

Definition (CSP)plant genus of the family Cannabacae and the dried flowering tops which contain hallucinogens.
Definition (MSH)The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.
ConceptsPlant (T002)
EnglishCannabis, Hemp Plant
Parent ConceptsMarihuana (C0024808), Angiosperms (C0330208), Hemp family (C0446240)
SourcesAOD, CSP, LCH, MSH, MTH, NCBI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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