Infectious Disease Book

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Mefloquine

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  1. Indications
    1. Prophylaxis or Treatment of Malaria
    2. Preferred agent in Chloroquine resistance areas
  2. Contraindications
    1. History of Epilepsy (Seizure disorder)
    2. History of psychiatric disorder
    3. Concomitant Beta Blocker use
  3. Pharmacokinetics
    1. Half-life: 33 days
    2. Steady state reached
      1. Weekly dose: 7 weeks
      2. Loading dose: 4 days
  4. Adverse Effects
    1. Neuropsychological effects (rare, 1:200 to 1:500)
      1. Insomnia
      2. Nightmares
      3. Anxiety
      4. Irritability
      5. Major Depression
      6. Psychosis or Seizures (rare)
        1. Prophylaxis Incidence: <1:10,000
        2. Treatment Incidence: 1:100 to 1:1500
    2. Pregnancy
      1. No significant adverse fetal affects in studies
  5. Directions
    1. Take with food and full glass of water
  6. Dosing: Prophylaxis
    1. Protocol
      1. Start dosing 1 week before exposure
      2. Complete dosing 4 weeks after exposure
    2. Adult
      1. Mefloquine 228 mg base (250mg salt) PO once weekly
    3. Child
      1. Weight <15 kg
        1. Dose: 4.6 mg/kg base (5 mg/kg salt) PO once weekly
      2. Weight 15-19 kg
        1. Mefloquine 1/4 tablet PO once per week
      3. Weight: 20-30 kg
        1. Mefloquine 1/2 tablet PO once per week
      4. Weight: 31-45 kg
        1. Mefloquine 3/4 tablet PO once per week
      5. Weight: >45 kg
        1. Mefloquine 1 tablet PO once per week
  7. Dosing: Treatment
    1. Adult: 1250 mg for 1 dose
    2. Child: 15 mg/kg for 1 dose
  8. References
    1. Boudreau (1993) Trop Med Parasitol 44(3):257
    2. Vanhauwere (1998) Am J Trop Med Hyg 58:17
    3. Weimeke (1991) Am J Trop Med Hyg 45:86

Mefloquine (C0025153)

Definition (MSH)A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD015767
EnglishMefloquine, MEFLOQUINE PREPARATION, Mefloquine product, Mephloquine
Spanishmefloquina
Parent ConceptsQuinolines (C0034424), Antimalarials (C0003374), Aminoquinoline antimalarial (C0360395)
SourcesLNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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