II. Background

  1. Produced first in 1958 from penicillium

III. Indications

IV. Duration

  1. Tinea Capitis
    1. Treated for 6-8 weeks (durations up to 16 weeks have been used previously) or
    2. Two weeks after cultures are negative

V. Efficacy

  1. Very effective for Tinea Capitis over 2-4 months
  2. Not as effective for Tinea Unguium

VI. Dosing

  1. Ultrasize preparations are also available but are significantly more expensive (but better absorption)
  2. Griseofulvin microsize (Griseofulvin V)
    1. Adults: 500 mg (up to 1 g) orally daily
    2. Child: 10-20 mg/kg/day (up to 20-25 mg/kg/day, maximum 1 g/day) until Hair Growth

VII. Monitoring

  1. No baseline testing needed in the absence of liver disease
  2. Obtain labs for treatment duration >8 weeks (or history of abnormal Liver Function Tests)
    1. Liver Function Tests (ALT, AST, Serum Bilirubin) every 8 weeks
    2. Complete Blood Count (CBC) every 8 weeks
    3. Serum Creatinine every 8 weeks

VIII. Directions

  1. Take with food (especially a fatty meal) for better absorption

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Cost: Medications

griseofulvin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
GRISEOFULVIN 125 MG/5 ML SUSP Generic $0.19 per ml
GRISEOFULVIN MICRO 500 MG TAB Generic $6.36 each
GRISEOFULVIN ULTRA 125 MG TAB Generic $3.17 each
GRISEOFULVIN ULTRA 250 MG TAB Generic $4.25 each

Ontology: Griseofulvin (C0018242)

Definition (NCI) An antifungal agent derived from the mold Penicillium griseofulvum that is used to treat fungal infections of the skin and nails. Griseofulvin binds to tubulin, disrupting microtubule function and inhibiting mitosis.
Definition (MSH) An antifungal agent used in the treatment of TINEA infections.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D006118
SnomedCT 372807004, 64349004
LNC LP18091-6, MTHU003374
English Griseofulvin, Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-, griseofulvin, griseofulvin (medication), Griseofulvin [Chemical/Ingredient], GRISEOFULVIN, Griseofulvin (product), Griseofulvin (substance)
Swedish Griseofulvin
Czech griseofulvin
Finnish Griseofulviini
Russian GRIZEOFUL'VIN, ГРИЗЕОФУЛЬВИН
Japanese グリセオフルビン
Croatian GRIZEOFULVIN
Polish Likuden, Fulcyna, Gryzeofulwina
Spanish griseofulvina (producto), griseofulvina (sustancia), griseofulvina, Griseofulvina
French Griséofulvine
German Griseofulvin
Italian Griseofulvin
Portuguese Griseofulvina