Human Immunodeficiency Virus Book

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Adefovir

Aka: Adefovir, Preveon
  1. See Also
    1. Anti-Retroviral Therapy
    2. Nucleoside Reverse Transcriptase Inhibitor
  2. Mechanism
    1. Nucleoside Reverse Transcriptase Inhibitor
  3. Dosing
    1. Adefovir 120 mg PO qd
    2. Take with L-carnitine 500 mg supplement
  4. Adverse Effects
    1. Nephrotoxicity (30%)
      1. Fanconi Syndrome like condition
    2. Nausea
    3. Diarrhea
    4. Asthenia
    5. Liver Function Test abnormalities
  5. Availability
    1. Phone: 1-800-445-3235
  6. References
    1. (1998) Med Lett Drugs Ther 40(1041):115
    2. (2009) Treat Guidel Med Lett 7(78): 11-22

Preveon (C0754613)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C106812
English Preveon
Sources
Derived from the NIH UMLS (Unified Medical Language System)


adefovir (C0050175)

Definition (NCI) An acyclic nucleotide adenine analogue of adenosine monophosphate and reverse transcriptase inhibitor with potent antiviral activity against hepatitis B virus (HBV). Adefovir is activated in vivo to a diphosphate metabolite by cellular kinases. In turn, adefovir diphosphate competes with the natural substrate deoxyadenosine triphosphate (dATP) for incorporation into viral DNA by competing with the natural substrate deoxyadenosine triphosphate (dATP), leading to viral RNA-dependent HBV DNA polymerase inhibition, DNA chain termination and impairment of viral replication.
Definition (CSP) an adenine analog, antiviral agent; used for treating hepatitis, HIV and African swine fever virus infections.
Concepts Nucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
MSH C053001
SnomedCT 412073001, 412072006
English 9-(2-phosphonylmethoxyethyl)adenine, 9-PMEA, 9-(2-phosphonomethoxyethyl)adenine, ADEFOVIR, PMEA, Phosphonylmethoxyethyl-a, adefovir, adefovir [Chemical/Ingredient], 9-(2-phophonylmethoxyethyl)adenine, Adefovir (product), Adefovir (substance), Adefovir
Spanish adefovir (producto), adefovir (sustancia), adefovir
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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