http://www.fpnotebook.com/
EtomidateAka: Amidate
- Mechanism
- Imidazole derivative
- Sedation agent with minimal Analgesic effect
- Contraindications
- Hypersensitivity to Etomidate
- Indication
- Agent of choice in adult Conscious Sedation
- Fracture or dislocation reduction
- Significant Wound Debridement
- Rectal foreign body
- Ketamine is usually preferred in children
- Sedation in Rapid Sequence Intubation
- Intubation Agent of choice in Trauma
- Intubation agent of choice in Heart Failure
- Dose: Sedation prior to intubation
- Adult: 0.2 mg/kg over 30-60 seconds IV
- Child: 0.2-0.3 mg/kg IV
- Ketamine is usually preferred in children
- Pharmacokinetics
- Onset: Within 1 minute of IV dose
- Duration: 3-5 minutes (up to 10 minutes in some cases)
- Metabolized by liver
- Effect may be prolonged in liver failure
- Pregnancy
- Pregnancy Category C
- Adverse effects
- Nausea or Vomiting on emergence from agent
- Muscle twitching
- Respiratory depression in up to 15% of cases
- Responds to Supplemental Oxygen
- Positive Pressure Ventilation is rarely needed
- Adrenal suppression (not Clinically Significant)
- References
- Brown (2005) Am Fam Physician 71:85
- Vinson (2002) Ann Emerg Med 39:592
|
|---|
| Definition (MSH) | Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. |
| Definition (NCI) | An imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
|
| English | Ethomidate, Etomidate, ETOMIDATE PREPARATION |
| Spanish | etomidato |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
|
Navigation Tree