Gynecology Book

http://www.fpnotebook.com/

Third Generation ProgestinAka: Norgestrel, Levonorgestrel

Advertisement

  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Class
    1. 19 Nor-Testosterone Progestin: Gonane
  3. dl-Norgestrel
    1. Relative Progestational Activity: 2.6
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 4.2
      3. Endometrial Activity: 2.6
      4. Anti-Estrogen: Active
      5. Anabolic: Active
    2. Preparations
      1. Ethinyl Estradiol
        1. Lo-Ovral (0.3/30)
        2. Ovral (0.5/50)
      2. Progesterone only OCP (Mini-Pill)
        1. Ovrette (0.075)
  4. Levonorgestrel
    1. Relative Progestational Activity: 5.3
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 8.3
      3. Endometrial Activity: 5.1
      4. Anti-Estrogen: Active
      5. Anabolic: Active
    2. Preparations with Ethinyl Estradiol
      1. Alesse (0.1/20)
      2. Nordette (0.15/30)
      3. Monofeme (0.15/30)
      4. Levlen (0.15/30)
      5. Triphasil (0.05/30 - 0.075/40 - 0.125/30)
      6. Seasonale (0.15/30)
  5. Adverse Effects
    1. See Oral Contraceptive
    2. Higher risk of thromboembolism than other OCPs
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
    2. Speroff (1993) Obstet Gynecol 81:1034
    3. Dickey (1998) Managing Contraceptive Pill Patients

Levonorgestrel (C0023566)

Definition (MSH)A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Definition (NCI)The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.
Definition (CSP)a synthetic progestational hormone; can be delivered through different routes including capsules inserted under the skin as in Norplant.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishD Norgestrel, l Norgestrel, Levonogestrel, Levonorgestrel, Levonorgestrel preparation, Levonorgestrel product, NORGESTREL L
Spanishlevonorgestrel, preparado con levonorgestrel
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Norgestrel (C0028368)

Definition (MSH)A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis.
Definition (PDQ)A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39310&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39310&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C703" NCI Thesaurus)
Definition (NCI)A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04)
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishDL Norgestrel, NORGES, Norgestrel, Norgestrel preparation
Spanishnorgestrel, preparado con norgestrel
CreditsDerived from the NIH UMLS (Unified Medical Language System)



Navigation Tree