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EstrogenAka: Ethinyl Estradiol, Mestranol

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  1. See Also
    1. Estrogen Replacement Therapy (Hormone Replacement)
    2. Oral Contraceptive
  2. Symptoms of Excess Estrogen (e.g. Premenstrual Syndrome)
    1. Swollen or engorged breast tenderness
    2. Water retention
    3. Irritability
    4. Headaches
    5. Visual disturbance
    6. Memory difficulty
    7. Sweet craving
  3. Relative Potency
    1. Ethinyl Estradiol: 100
    2. Mestranol: 67
  4. Precautions
    1. Mestranol is potentially a carcinogen (animal studies)
  5. Preparations: Hormone Replacement dosage
    1. Ethinyl Estradiol
      1. Hormone Replacement: 0.005 to 0.02 mg/day
      2. Oral Contraceptive: 0.03 to 0.10 mg/day
    2. Micronized estradiol (1-2 mg/day)
    3. Estradiol Cypionate (2-5 mg every 3-4 weeks)
    4. Estradiol valerate (2-20 mg every other week)
    5. Estropipate (1.25-2.5 mg/day)
    6. Conjugated Estrogen (e.g. Premarin)
      1. Oral (0.3-1.25 mg/day)
      2. Injectable (0.2-2 mg/day)
      3. Transdermal
    7. Diethylstilbestrol (0.1-0.5 mg/day)
    8. Quinestrol (0.1-0.2 mg/week)
    9. Chlorotrianisene (12-25 mg/day)
    10. Methallenestril (3-9 mg/day)
    11. Esterified Estrogen (Menest): 0.3 to 1.25 mg/day

Estrogens (C0014939)

Definition (MSH)Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Definition (CSP)hormones which stimulate the female reproductive organs, and the development of secondary female sex characteristics.
Definition (NCI)A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI)
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD004967
EnglishEstrogen, Estrogen product, Estrogenic Agents, Estrogenic Compounds, Estrogenic drug, Estrogenic preparation, Estrogens, ESTROGENS PREPARATION, Oestrogen, Oestrogen product, Oestrogenic drug, Oestrogenic preparation, Oestrogens, Therapeutic Estrogen
Spanishdroga estrogenica, estrogeno, estrogenos, preparado estrogenico
Parent ConceptsSteroid hormone (C0301818), Gonadal Steroid Hormones (C0036884), estratriene compound (C0178625), Hormones (C0019932), Estrogens (C0014939), [HS000] HORMONES / SYNTHETICS / MODIFIERS (C0973563), Unclassified Ingredients (C1372954), miscellaneous antineoplastic hormone and synthetic substitute (C0279177), Gonadal Hormones (C0301819), Duplicate concept (C1274013), Drug allergen (C1320237), Sex Hormones/Modifiers (C1579311)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Mestranol (C0025506)

Definition (MSH)The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.
Definition (NCI)A semisynthetic estrogen. Metabolized by the liver to ethynyl estradiol, mestranol serves as the estrogen component in several combination oral contraceptives. (NCI04)
ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHD008656
EnglishEthinyl Estradiol 3 Methyl Ether, Ethinyl Estradiol 3-Methyl Ether, ETHINYL ESTRADIOL METHYL ETHER 03, Mestranol, Mestranol preparation, Mestranol product
Spanishmestranol, preparado con mestranol
Parent ConceptsEthinyl Estradiol (C0015011), Estradiol (C0014912), Estrogens (C0014939), Contraceptives, Oral (C0009905), Mestranol (C0025506), Duplicate concept (C1274013)
SourcesCSP, LCH, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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