III. Adverse Effects: Hyperlipidemia

  1. Overall Effect
    1. Lowers HDL-2 to Total Cholesterol ratio
  2. Factors related to unfavorable HDL effects
    1. Higher Progestational Activity
    2. Lower Estrogen to Progestin ratio
  3. Progestins most adversely effecting lipid (androgen)
    1. Levonorgestrel
  4. Progestins with most favorable lipid effects
    1. Progestin only formulations (mini pill)
    2. Desogestrel
    3. Norethindrone (low dose)

IV. References

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Cost: Medications

progesterone (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PROGESTERONE 100 MG CAPSULE Generic $0.79 each
PROGESTERONE 200 MG CAPSULE Generic $1.37 each
PROGESTERONE OIL 50 MG/ML VL Generic $2.41 per ml

Ontology: Progestins (C0033306)

Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (CHV) a synthetic or natural hormone that mimics progesterone
Definition (NCI) Substances that produce effects similar to those of progesterone, the only natural progestogen. All other progestogens are synthetic and are often referred to as progestins. All progestogens have antiestrogenic and antigonadotropic properties.
Definition (NCI_NCI-GLOSS) Any natural or laboratory-made substance that has some or all of the biologic effects of progesterone, a female hormone.
Definition (CSP) class of drugs which mimic progesterone by promoting gestation.
Definition (MSH) Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D011372
SnomedCT 283016001, 20249007, 116614001, 419430000
LNC LP31481-2, LP31663-5
English Gestagens, Progestagens, Progestogens, PROGESTINS, progestational hormones, progestins (medication), progestins, Synthetic Progestagen, [HS800] PROGESTINS, Progestational agents, Progestational hormones, progestagen, gestagen, progestogens, progestogen, gestagens, progestagens, Progestins, Progestogen (product), Progestational Hormones, Gestagenic Agents, Progestational Agents, Progestational Compounds, Progestagenic Agents, Progestogen product, Progestational hormone (substance), Progestin preparation (product), Progestin preparation, Progestogen preparation, progestin, progesterone agent, Progestin preparation, NOS, Progestogen preparation, NOS, Progestin preparation (substance), Progestogen (substance), Progestogen, Progestin, Progestational hormone, Progestagen
French Médicaments progestatifs, Agents progestatifs, Hormones progestatives, Progestatifs, Progestines, Progestines synthétiques, Progestogènes
Swedish Progestiner
Czech gestageny, progestiny, progestogeny, hormony sekreční fáze menstruačního cyklu
Finnish Progestiinit
Italian Agenti progestageni, Progestine, Gestageni, Progestinici, Progestageni, Agenti gestageni, Agenti progestazionali, Composti progestazionali, Progestogeni, Ormoni progestazionali
Russian PROGESTAGENY, PROGESTATIVNYE GORMONY SINTETICHESKIE, PROGESTATIVNYE GORMONY, PROGESTATIVNYKH GORMONOV ANALOGI, PROGESTAGENY SINTETICHESKIE, GESTAGENY, PROGESTINOV ANALOGI, PROGESTINY, GESTATINOV ANALOGI, PROGESTINY SINTETICHESKIE, ГЕСТАГЕНЫ, ГЕСТАТИНОВ АНАЛОГИ, ПРОГЕСТАГЕНЫ, ПРОГЕСТАГЕНЫ СИНТЕТИЧЕСКИЕ, ПРОГЕСТАТИВНЫЕ ГОРМОНЫ, ПРОГЕСТАТИВНЫЕ ГОРМОНЫ СИНТЕТИЧЕСКИЕ, ПРОГЕСТАТИВНЫХ ГОРМОНОВ АНАЛОГИ, ПРОГЕСТИНОВ АНАЛОГИ, ПРОГЕСТИНЫ, ПРОГЕСТИНЫ СИНТЕТИЧЕСКИЕ
Japanese プロゲストーゲン, ゲスターゲン, プロゲスチン, ゲスターゲン類, 月経前期ホルモン
Spanish preparado con progestágeno (producto), progestágeno, progestágeno (producto), preparado con progestágeno, Efecto Progestina, hormona progestacional (sustancia), hormona progestacional, preparado de progestina (producto), preparado de progestina (sustancia), preparado de progestina, preparado de progestágeno, Progestinas, Progestógenos
Polish Progestageny
Portuguese Efeito Progestina, Progestinas, Progestógenos
German Gestagene Hormone, Gestagene, Progestine, Progestogene, Progestagene

Ontology: Progesterone (C0033308)

Definition (CHV) a type of female sex hormone
Definition (CHV) a type of female sex hormone
Definition (NCI) Produced in the corpus luteum and by the placenta, as an antagonist of estrogens. Promotes proliferation of uterine mucosa and the implantation of the blastocyst, prevents further follicular development.(On-line Medical Dictionary)
Definition (NCI_NCI-GLOSS) A type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone can also be made in the laboratory. It may be used as a type of birth control and to treat menstrual disorders, infertility, symptoms of menopause, and other conditions.
Definition (NCI) A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. (NCI04)
Definition (CSP) principal progestational hormone, secreted by the corpus luteum, placenta, and in minute amounts by the adrenal cortex; it prepares the uterus for the reception and development of the fertilized ovum; it acts on the mammary glands and on the brain; it serves as an intermediate in the biosynthesis of sex steroids and adrenal corticosteroids.
Definition (MSH) The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Definition (PDQ) A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39059&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39059&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C777" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D011374
SnomedCT 50318003, 16683002
LNC LP14041-5, MTHU003615
English Progesterone, Pregn-4-ene-3,20-dione, Therapeutic Progesterone, progesterone, 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione, progestrogens progesterone, progesterone (medication), luteal hormone, PROGESTERONE, Progesterone [Chemical/Ingredient], progesterones, Corpus luteum hormone, Pregnenedione, Luteal hormone, Luteine, Pregnendione preparation, Progesterone preparation, Progesterone product, PRG - Progesterone, Progesterone (substance), Progesterone preparation (product), PRG, Progesterone preparation (substance), Delta4-pregnene-3,20-dione, Corpus Luteum Hormone
Swedish Progesteron
Czech progesteron, progestin
Finnish Progesteroni
French Prégnènedione, Progestérone
Russian PROGESTERON, ПРОГЕСТЕРОН
Japanese ルテウム, プロルトン, プロゲホルモン, プロゲステロン, プロジェステロン
Spanish preparación con pregnendiona, preparado con progesterona (producto), progesterona (producto), preparado con progesterona, progesterona, preparación de pregnendiona, preparado de progesterona (producto), preparado de progesterona (sustancia), preparado de progesterona, progesterona (sustancia), Progesterona
Italian Pregnenedione, Progesterone
Croatian PROGESTERON
Polish Progesteron
Norwegian Gestagen, Progesteron
German Progesteron
Portuguese Progesterona