Gynecology Book

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ProgesteroneAka: Progestin

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  1. See Also
    1. Oral Contraceptive
  2. Types
    1. First Generation Progestin
      1. Norethindrone (e.g. Ortho-Novum)
      2. Norethynodrel (Enovid)
    2. Second Generation Progestin
      1. Norethindrone Acetate (e.g. Loestrin)
      2. Ethynodiol Diacetate (e.g. Demulen)
    3. Third Generation Progestin
      1. Levonorgestrel (e.g. Triphasil)
      2. dl-Norgestrel (e.g. Ovral)
    4. Fourth Generation Progestin
      1. Desogestrel (e.g. Desogen)
      2. Gestodene
      3. Norgestimate (e.g. Ortho-Cyclen)
    5. Pregnane Progestin
      1. Chlormadinone acetate
      2. Megestrol acetate
      3. Medroxyprogesterone acetate
  3. Adverse Effects: Hyperlipidemia
    1. Overall Effect
      1. Lowers HDL-2 to Total Cholesterol ratio
    2. Factors related to unfavorable HDL effects
      1. Higher Progestational Activity
      2. Lower Estrogen to Progestin ratio
    3. Progestins most adversely effecting lipid (androgen)
      1. Levonorgestrel
    4. Progestins with most favorable lipid effects
      1. Progestin only formulations (mini pill)
      2. Desogestrel
      3. Norethindrone (low dose)
  4. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
    2. Speroff (1993) Obstet Gynecol 81:1034
    3. Dickey (1998) Managing Contraceptive Pill Patients

Progestins (C0033306)

Definition (CSP)class of drugs which mimic progesterone by promoting gestation.
Definition (MSH)Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Definition (NCI)A hormone secreted in the uterus controlling ovum implantation.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishGestagenic Agents, Gestagens, Progestagen, Progestagenic Agents, Progestagens, Progestational Agents, Progestational Compounds, Progestational hormone, Progestational Hormones, progesterone agent, Progesterone Agents, progestin, Progestin preparation, Progestins, Progestogen, Progestogen preparation, Progestogen product, Progestogens, Therapeutic Progestogen
Spanishhormona progestacional, preparado con progestágeno, preparado con progestageno, preparado de progestágeno, preparado de progestageno, preparado de progestina, progestágeno, progestageno
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Progesterone (C0033308)

Definition (MSH)The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Definition (CSP)principal progestational hormone, secreted by the corpus luteum, placenta, and in minute amounts by the adrenal cortex; it prepares the uterus for the reception and development of the fertilized ovum; it acts on the mammary glands and on the brain; it serves as an intermediate in the biosynthesis of sex steroids and adrenal corticosteroids.
Definition (NCI)(pro-JES-ter-own) A female hormone.
Definition (PDQ)A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39059&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39059&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C777" NCI Thesaurus)
Definition (NCI)Produced in the corpus luteum and by the placenta, as an antagonist of estrogens. Promotes proliferation of uterine mucosa and the implantation of the blastocyst, prevents further follicular development.
Definition (NCI)A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. (NCI04)
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishCorpus luteum hormone, Luteal hormone, Luteine, Pregnendione preparation, Pregnenedione, PRG, Progesterone, PROGESTERONE PREPARATION, Progesterone product, Therapeutic Progesterone
Spanishpreparación con pregnendiona, preparación de pregnendiona, preparacion con pregnendiona, preparacion de pregnendiona, preparado con progesterona, preparado de progesterona, progesterona
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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