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Progestin Endometrial ActivityAka: Endometrial Activity

See Also
1. Oral Contraceptive
2. Progestin
General
1. Ability to prevent spotting or breakthrough bleeding
2. Dependent on Estrogen-Progestin ratio
3. Bleeding may be due to:
  1. Estrogen insufficiency
  2. Progesterone insufficiency
Progestins with least potent endometrial activity
1. Amount to suppress bleeding for 20 days in 50% women
2. Gestodene (12.6)
3. Desogestrel (8.7)
4. Levonorgestrel (5.1)
5. dl-Norgestrel (2.6)
Progestins with most endometrial activity
1. Amount to suppress bleeding for 20 days in 50% women
2. Norethynodrel (0): Low limit reference
3. Norethindrone Acetate (0.4)
4. Ethynodiol Diacetate (0.4)
5. Norethindrone (1.0)
Oral Contraceptives with least endometrial activity
1. Least suppression of bleeding
2. Progestin-Only (Mini-Pill)
3. Demulen 1/35
4. Loestrin
5. Tri-Norinyl
Oral Contraceptives with most endometrial activity
1. Greatest suppression of bleeding
2. Ovral
3. Lo-Ovral
4. Ortho Novum
5. Ovcon
6. Norlestrin
7. Demulen 50
References
1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
2. Speroff (1993) Obstet Gynecol 81:1034
3. Dickey (1998) Managing Contraceptive Pill Patients

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.