Gynecology Book

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First Generation ProgestinAka: Norethindrone, Norethynodrel

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  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Class
    1. 19 Nor-Testosterone Progestin: Estrane
  3. Norethindrone
    1. Relative Progestational Activity: 1.0
      1. Estrogenic Activity: 1.0
      2. Androgenic Activity: 1.0
      3. Endometrial Activity: 1.0
      4. Anti-Estrogen: Active
    2. Preparations
      1. Ethinyl Estradiol
        1. Brevicon, Modicon (0.5/35)
        2. Ovcon (0.4/35, 1/50)
        3. Norinyl, Ortho-Novum 1/35
        4. Ortho-Novum 10/11 Biphasic (0.5-1.0/35)
        5. Ortho-Novum 7/7/7 Triphasic (0.5-0.75-1.0/35)
        6. Tri-Norinyl Triphasic (0.5-1.0-0.5/35)
      2. Mestranol
        1. Norinyl, Ortho-Novum (1/50, 1/80, 2/100)
      3. Progestin-only (Mini-Pill)
        1. Micronor, Nor-QD (0.35)
  4. Norethynodrel
    1. Relative Progestational Activity: 0.3
      1. Estrogenic Activity: 8.3
      2. Androgenic Activity: 0
      3. Endometrial Activity: 0
      4. Anti-Estrogen: Inactive
    2. Preparations (Mestranol Estrogen component)
      1. Enovid 5 (5/75)
      2. Enovid E (2.5/100)
  5. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
    2. Speroff (1993) Obstet Gynecol 81:1034
    3. Dickey (1998) Managing Contraceptive Pill Patients

Norethindrone (C0028356)

Definition (MSH)A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Definition (CSP)synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation; has weak estrogenic and androgenic properties; has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Definition (NCI)A synthetic progestational substance with some anabolic, estrogenic, and androgenic properties. Norethindrone binds to the progesterone intracellular receptors in the reproductive system and the resultant activated complex interacts with specific DNA sites. This leads to an alteration in protein synthesis and results in an inhibition of LH release. Consequently, it inhibits ovulation and changes the normal cycle of cervical mucus and endometrium.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishEthinylnortestosterone, Norethindrone, Norethindrone preparation, Norethisterone, Norethisterone preparation, Norethisterone product, Norpregneninolone
Spanishnoretindrona, preparado con noretindrona, preparado con noretisterona
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Norethynodrel (C0028360)

Definition (MSH)A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishNorethynodrel, Norethynodrel preparation, Noretynodrel
Spanishnoretinodrel, preparado con noretinodrel
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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