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Fourth Generation ProgestinAka: Desogestrel, Gestodene, Norgestimate

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  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Class
    1. 19 Nor-Testosterone Progestin: Gonane
  3. Desogestrel
    1. Relative Progestational Activity: 9.0
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 3.4
      3. Endometrial Activity: 8.7
    2. Preparations
      1. Desogen (0.15/30)
      2. Ortho-Cept (0.15/30)
      3. Mircette (0.15/20)
      4. Cyclessa (triphasic: 0.100 - 0.125 - 0.150 / 25)
  4. Gestodene
    1. Relative Progestational Activity: 12.6
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 8.6
      3. Endometrial Activity: 12.6
  5. Norgestimate
    1. Relative Progestational Activity: 1.3
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 1.9
      3. Endometrial Activity: 1.2
    2. Preparations
      1. Ortho-Cyclen (0.15/30)
      2. Ortho Tri-Cyclen (0.18/35 - 0.25/35)
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
    2. Speroff (1993) Obstet Gynecol 81:1034
    3. Dickey (1998) Managing Contraceptive Pill Patients

Desogestrel (C0057558)

Definition (MSH)A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Definition (NCI)A synthetic progestogen with progesterone hormone receptor agonistic activity. Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. This leads to an inhibition of LH release and prevents ovulation and alters the cervical mucus. Desogestrel is used in birth control pills alone or in combination with estrogens.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD017135
EnglishDesogestrel, Desogestrel preparation, Desogestrel product
Spanishdesogestrel, preparado con desogestrel
Parent ConceptsNorpregnenes (C0028397), Progestins (C0033306), [HS200] CONTRACEPTIVES, SYSTEMIC (C0973564), Contraceptives, Oral (C0009905), Norsteroids (C0028401), Progestational Hormones, Synthetic (C0033307), Duplicate concept (C1274013)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Gestodene (C0061246)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHC033273
EnglishGestoden, Gestodene
Spanishgestodeno
Parent ConceptsCombined Oral Contraceptives (C0009906), Progestational Hormones, Synthetic (C0033307)
SourcesMSH, RXNORM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


norgestimate (C0068992)

ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSHC017576
Englishnorgestimate, Norgestimate preparation
Spanishnorgestimato, preparado con norgestimato
Parent ConceptsProgestins (C0033306), Norgestrel (C0028368), Contraceptives, Oral (C0009905), Combined Oral Contraceptives (C0009906), Progestational Hormones, Synthetic (C0033307), Drug allergen (C1320237)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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