Gynecology Book

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Fourth Generation Progestin

Aka: Fourth Generation Progestin, Desogestrel, Gestodene, Norgestimate
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Class
    1. 19 Nor-Testosterone Progestin: Gonane
  3. Desogestrel
    1. Relative Progestational Activity: 9.0
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 3.4
      3. Endometrial Activity: 8.7
    2. Preparations
      1. Desogen (0.15/30)
      2. Ortho-Cept (0.15/30)
      3. Mircette (0.15/20)
      4. Cyclessa (triphasic: 0.100 - 0.125 - 0.150 / 25)
  4. Gestodene
    1. Relative Progestational Activity: 12.6
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 8.6
      3. Endometrial Activity: 12.6
  5. Norgestimate
    1. Relative Progestational Activity: 1.3
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 1.9
      3. Endometrial Activity: 1.2
    2. Preparations
      1. Ortho-Cyclen (0.15/30)
      2. Ortho Tri-Cyclen (0.18/35 - 0.25/35)
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073
    2. Speroff (1993) Obstet Gynecol 81:1034-47
    3. Dickey (1998) Managing Contraceptive Pill Patients

Desogestrel (C0057558)

Definition (MSH) A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Definition (NCI) A synthetic progestogen with progesterone hormone receptor agonistic activity. Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. This leads to an inhibition of LH release and prevents ovulation and alters the cervical mucus. Desogestrel is used in birth control pills alone or in combination with estrogens.
Concepts Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSH D017135
SnomedCT 116074007, 326306004, 126108008
English 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol, Desogestrel, 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol, 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17alpha)-, 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol, desogestrel, DESOGESTREL, Desogestrel [Chemical/Ingredient], alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17, Desogestrel (substance), Desogestrel preparation (product), Desogestrel preparation, Desogestrel product, Desogestrel [dup] (substance), Desogestrel preparation (substance)
Swedish Desogestrel
Czech desogestrel
Spanish Desogestrel [dup] (substance), Desogestrel, desogestrel (producto), preparado con desogestrel (producto), preparado con desogestrel, desogestrel (sustancia), desogestrel, preparado de desogestrel (sustancia)
Finnish Desogestreeli
Russian DESGESTREL, ДЕСГЕСТРЕЛ
Japanese デソゲストレル
Italian 13-Etil-11-metilene-18,19-dinor-17 alfa-pregn-4-en-20-yn-17-ol, Desogestrel
Polish Dezogestrel
French Désogestrel
German Desogestrel
Portuguese Desogestrel
Sources
Derived from the NIH UMLS (Unified Medical Language System)


norgestimate (C0068992)

Concepts Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSH C017576
SnomedCT 326362004, 126115000, 116073001
English norgestimate, Norgestimate [combined oc], NORGESTIMATE, Norgestimate [combined oc] (product), norgestimate [Chemical/Ingredient], Norgestimate (substance), Norgestimate preparation (product), Norgestimate preparation, Norgestimate, Norgestimate [combined oc] (substance), Norgestimate preparation (substance)
Spanish norgestimato (anticonceptivo oral combinado), norgestimato (anticonceptivo oral combinado) (producto), preparado con norgestimato (producto), norgestimato (producto), preparado con norgestimato, norgestimato (sustancia), norgestimato, preparado de norgestimato (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Gestodene (C0061246)

Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C033273
SnomedCT 326352006, 437760006, 395945000
English 13-ethyl-17-hydroxy-18,19-dinor-17 alpha-pregna-4,15-dien-20-yn-3-one, 17-alpha-ethinyl-13-ethyl-17 beta-hydroxy-4,15-gonadien-3-one, Gestoden, Gestodene, Gestodene [combined oc], Gestodene [combined oral contraceptive], Gestodene [combined oral contraceptive] (product), Gestodene (product), GESTODENE, gestodene, gestoden, 13-Ethyl-17-Hydroxy-18,19-Dinor-17.Alpha.-Pregna-4,15-Dien-20-Yn-3-One, Pregna-4,15-Dien-20-Yn-3-One, 13-Ethyl-17-Hydroxy-18,19-Dinor-, (17.Alpha.)-, 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)-, Gestodene (substance), Gestodene [combined oral contraceptive] (substance)
Spanish gestodeno (anticonceptivo oral combinado), gestodeno (anticonceptivo oral combinado) (producto), gestodeno (producto), gestodeno (sustancia), gestodeno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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