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Non-Nucleoside Reverse Transcriptase InhibitorAka: NNRTI

Mechanism
1. Bind directly to reverse transcriptase
2. Prevents RNA conversion to DNA
3. Completely different mechanism than nRTI
Preparations
1. Delavirdine (Rescriptor)
2. Efavirenz (Sustiva)
3. Nevirapine (Viramune)
Adverse Reaction
1. Rash is common (especially with Nevirapine)
  1. More common and more severe in women
  2. Reduced Incidence if start dose slowly over 2 weeks
  3. Prophylaxis not recommended (e.g. Corticosteroids)
    1. Antinori (2001) {a 10211} 15:1579
  4. Switching to a different NNRTI not recommended

Non-Nucleoside Reverse Transcriptase Inhibitors (C1373120)
Concepts	Pharmacologic Substance (T121)
English	Non-Nucleoside Reverse Transcriptase Inhibitors
Parent Concepts	Reverse Transcriptase Inhibitors (C0282519)
Sources	NDFRT Derived from the NIH UMLS (Unified Medical Language System)

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.

Human Immunodeficiency Virus Book

Approach

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Non-Nucleoside Reverse Transcriptase Inhibitor

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Non-Nucleoside Reverse Transcriptase InhibitorAka: NNRTI

Non-Nucleoside Reverse Transcriptase Inhibitors (C1373120)

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