II. Dosing: Adult

  1. Betamethasone (Celestone) 0.5 to 0.9 mg IM/PO qd
  2. Cortisone (Cortone) 25-300 mg PO qd
  3. Dexamethasone (Decadron) 0.5-9 mg/day PO/IM/IV divided q6h
  4. Hydrocortisone (Cortef)
    1. Parenteral: 100 to 150 mg IV/IM q2-6 hours prn
    2. Oral: 20 to 240 mg/day PO in divided dosing
  5. Methylprednisolone
    1. Parenteral (Solu-Medrol) 10 to 125 mg IV/IM
    2. Oral (Medrol) 4 to 48 mg PO qd
    3. Medrol Dose pack: tapers from 24 to 0 PO over 7 days
  6. Triamcinolone (Aristocort, Kenalog) 4 to 48 mg PO/IM qd
  7. Prednisolone (Prelone) 5-60 mg PO/IV/IM qd
  8. Prednisone (Deltasone) 5-60 mg PO qd
  9. Rayos (delayed release version of Prednisone)
    1. Marketed to reduce morning inflammation in Rheumatoid Arthritis
    2. Taken at 10 pm with intended release starting at 2 am
    3. Unlikely to add significant benefit for the cost (more than $200 for thirty 5 mg tabs)
    4. (2012) Prescr Lett 19(12): 69

III. Dosing: Child

  1. Methylprednisolone (Solu-Medrol)
    1. Dose: 1-2 mg/kg/dose PO/IV/IM q6h up to 125 mg/dose
  2. Prednisolone (Prelone)
    1. Dose: 1-2 mg/kg/dose PO qd to bid up to 60 mg/day
    2. Maximum: 60 mg per day
    3. Preparations
      1. Syrup: 15 mg/5 ml
      2. Liquid: 5 mg/5 ml
  3. Dexamethasone
    1. Asthma Exacerbation: 0.3 to 0.6 mg/kg/day up to 15 mg for 1-2 days
    2. Croup: 0.15 to 0.6 mg/kg once up to 10 mg
      1. See Dexamethasone in Croup

IV. Agents: Overall potency (equivalent dosages)

  1. High potency
    1. Betamethasone 0.6 to 0.75 mg
    2. Dexamethasone 0.75 mg
  2. Medium potency
    1. Methylprednisolone 4 mg
    2. Triamcinolone 4 mg
    3. Prednisolone 5 mg
    4. Prednisone 5 mg
  3. Low potency
    1. Hydrocortisone 20 mg
    2. Cortisone 25 mg

V. Agents: Relative anti-inflammatory potency

  1. High anti-inflammatory potency
    1. Betamethasone 20-30
    2. Dexamethasone 20-30
  2. Medium anti-inflammatory potency
    1. Methylprednisolone 5
    2. Triamcinolone 5
    3. Prednisolone 4
    4. Prednisone 4
  3. Low anti-inflammatory potency
    1. Hydrocortisone 1
    2. Cortisone 0.8

VI. Agents: Relative Mineralocorticoid Potency

  1. Mineralocorticoid Activity
    1. Cortisone 2
    2. Hydrocortisone 2
    3. Prednisolone 1
    4. Prednisone 1
  2. No Mineralocorticoid Activity
    1. Betamethasone
    2. Dexamethasone
    3. Methylprednisolone
    4. Triamcinolone

VII. Agents: Half Life

  1. Long half-life (36-54 hours)
    1. Betamethasone
    2. Dexamethasone
  2. Medium half-life (18-36 hours)
    1. Methylprednisolone
    2. Prednisolone
    3. Prednisone
    4. Triamcinolone
  3. Short half-life (8-12 hours)
    1. Cortisone
    2. Hydrocortisone

VIII. Adverse Effects (typically with Long-term Corticosteroid use)

  1. Corticosteroid Associated Osteoporosis
  2. Corticosteroid Myopathy
  3. Motor restlessness
  4. Hypertension
  5. Iatrogenic Diabetes Mellitus
  6. Hyperlipidemia
  7. Fluid retention
  8. Osteonecrosis of the hip
  9. Psychiatric effects
    1. Includes depression, anxiety, mania, Psychosis, Delirium and Insomnia
    2. Typically occurs in first week of therapy and resolves within a week of stopping the Corticosteroid
    3. Most have mild to moderate symptoms but may be severe in up to 5% of cases
    4. Symptoms may also occur (uncommonly) with high potency Topical Corticosteroids or intranasal Corticosteroids
    5. Incidence of psychiatric effects increases with dose
      1. Occurs in 1% of patients on Prednisone 40 mg orally daily or less
      2. Occurs in 5% of patients on Prednisone 40 mg to 80 mg orally daily or less
      3. Occurs in 18% of patients on Prednisone 80 mg orally daily or more
    6. References
      1. (2014) Presc Lett 21(12):69-70

IX. Prevention of Corticosteroid complications

Images: Related links to external sites (from Google)

Cost: Medications

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Ontology: Adrenal Cortex Hormones (C0001617)

Definition (NCI) Any steroid hormone made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias.
Definition (CSP) any of the 21-carbon steroids elaborated by the adrenal cortex (excluding the sex hormones of adrenal origin) in response to adrenocorticotropic hormone (ACTH) released by the pituitary gland or to angiotensin II; called also adrenocorticoid, corticoid, adrenal cortical or adrenocortical steroid, and adrenocortical or cortical hormone.
Definition (NCI) Hormones synthesized in the cortex of the adrenal gland and consist of two subclasses, glucocorticoids (carbohydrate regulation) and mineralocorticoids (electrolyte regulation).
Concepts Steroid (T110) , Pharmacologic Substance(T121) , Hormone(T125)
MSH D000305
SnomedCT 332333008, 320476006, 79440004, 21568003
English Corticoid, Adrenal Cortex Hormones, Corticoids, Corticosteroids, Hormones, Adrenal Cortex, Adrenal cortical hormone, NOS, Corticoid preparation, NOS, Corticosteroids [resp], Corticosteroids [skin], Corticosteroids [skin] (product), Corticosteroids [respiratory use] (product), Corticosteroids [respiratory use], adrenal cortex hormone, corticosteroids, adrenal cortex hormones, corticoids, Corticosteroid [EPC], Adrenal Cortex Hormones [Chemical/Ingredient], Corticosteroid, Adrenal cortex hormones, adrenal corticosteroids, adrenal cortical hormone, adrenal corticosteroid, adrenocorticosteroids, corticoid, Adrenal cortical hormone, Adrenocorticosteroids, Corticoid preparation (product), Corticoid preparation, Adrenal cortical hormone (substance), corticosteroid, Corticoid preparation (substance), Corticosteroids [respiratory use] (substance), Corticosteroids [skin] (substance), Adrenal Cortex Steroids, Therapeutic Corticosteroid
Swedish Binjurebarkshormoner
Spanish corticosteroide (uso dermatológico), corticosteroide (uso dermatológico) (producto), corticosteroide [uso respiratorio] (producto), corticosteroide [uso respiratorio], corticoides (producto), preparado con corticoides (producto), corticoides, preparado con corticoides, Corticoesteroides, Corticosteroides, adrenocorticoesteroide, corticosteroides (piel) (producto), corticosteroides (piel), corticosteroides [uso respiratorio] (producto), corticosteroides [uso respiratorio], hormona de la corteza suprarrenal, hormona suprarrenal cortical (sustancia), hormona suprarrenal cortical, preparado de corticoides (producto), preparado de corticoides (sustancia), preparado de corticoides, Corticoides, Hormonas de la Corteza Suprarrenal
Czech hormony kůry nadledvin, kortikosteroidy, kortikoidy
Finnish Lisämunuaiskuoren hormonit
French Hormones cortico-surrénaliennes, Corticoïdes, Corticostéroïdes, Hormones corticosurrénaliennes
Italian Corticoidi, Corticosteroidi, Ormoni corticosurrenali
Russian NADPOCHECHNIKOV KORY GORMONY, KORTIKOSTEROIDY, KORTIKOIDY, КОРТИКОИДЫ, КОРТИКОСТЕРОИДЫ, НАДПОЧЕЧНИКОВ КОРЫ ГОРМОНЫ
Croatian KORTIKOSTEROIDI
Portuguese Corticoesteróides, Corticóides, Corticosteróides, Hormônios do Córtex Supra-Renal
Polish Hormony kory nadnerczy, Kortykoidy, Kortykosteroidy
Japanese コルチコイド, 副腎皮質ホルモン, コルチコステロイド, ステロイドホルモン-副腎皮質, 副腎皮質ステロイド
German Corticoide, Corticosteroide, Nebennierenrindenhormone

Ontology: Betamethasone (C0005308)

Definition (MSH) A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
Definition (NCI) A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
Definition (PDQ) A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39273&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39273&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C303" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance(T121) , Hormone(T125)
MSH D001623
SnomedCT 116571008, 29896003
English Betadexamethasone, Betamethasone, Flubenisolone, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-, betamethasone, betamethasone (medication), Betamethasone [Chemical/Ingredient], Betamethasone preparation, Flubenisolone preparation, Betamethasone (substance), Betamethasone preparation (product), Betamethasone preparation (substance), BETAMETHASONE
Swedish Betametason
Czech betamethason
Finnish Beetametasoni
Italian Betadesametasone, Flubenisolone, Betametasone
Russian BETADEKSAMETAZON, BETAMETAZON, FLUBENIZOLON, БЕТАДЕКСАМЕТАЗОН, БЕТАМЕТАЗОН, ФЛУБЕНИЗОЛОН
Spanish preparado de betametasona (producto), betametasona (producto), preparado de flubenisolona, preparado de betametasona, betametasona (sustancia), betametasona, preparado de betametasona (sustancia), Betadexametasona, Betametasona, Flubenisolona
Polish Flubenisolonum, Betametazon
Japanese フルベニソロン, ベタメタゾン, ベタデキサメタゾン
French Bétaméthasone
German Betadexamethason, Betamethason, Flubenisolon
Portuguese Betadexametasona, Betametasona, Flubenisolona

Ontology: Cortisone (C0010137)

Definition (NCI) A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation.
Definition (MSH) A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Definition (CSP) naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol.
Definition (NCI) A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses.
Definition (NCI) A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat.
Concepts Steroid (T110) , Pharmacologic Substance(T121) , Hormone(T125)
MSH D003348
SnomedCT 32498003, 111150008
English cortisone, Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 17,21-Dihydroxypregn-4-ene-3,11,20-trione, Cortisone, Cortisone [Chemical/Ingredient], cortisones, Compound E, Cortisone preparation, Cortisone (substance), Cortisone preparation (product), Cortisone product, CORT, Cortisone preparation (substance), Therapeutic Cortisone, CORTISONE
Swedish Kortison
Czech kortison
Finnish Kortisoni
Russian KORTIZON, КОРТИЗОН
Japanese コルチゾン, 11-デヒドロ-17-ヒドロキシコルチコステロン
Spanish preparado con cortisona (producto), cortisona (producto), preparado con cortisona, cortisona (sustancia), cortisona, preparado de cortisona (producto), preparado de cortisona (sustancia), preparado de cortisona, Cortisona
Croatian KORTIZON
Polish Kortyzon
French Cortisone
German Cortison
Italian Cortisone
Portuguese Cortisona

Ontology: Dexamethasone (C0011777)

Definition (CHV) a kind of steroid drug
Definition (CHV) a kind of steroid drug
Definition (CSP) anti-inflammatory 9-fluoro-glucocorticoid.
Definition (MSH) An anti-inflammatory 9-fluoro-glucocorticoid.
Definition (PSY) A synthetic analogue of cortisol.
Definition (NCI) A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
Definition (NCI) A synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment.
Definition (PDQ) A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39789&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39789&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C422" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance(T121)
MSH D003907
SnomedCT 325354000, 372584003, 7561000, 116568000
English Dexamethasone, Hexadecadrol, Methylfluorprednisolone, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-, 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone, 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, 9Alpha-fluoro-16alpha-methylprednisolone, 9alpha-Fluoro-16alpha- methylprednisolone, Fluoro-9alpha Methyl-16alpha Prednisolone, (11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione, 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone, 16Alpha-methyl-9alpha-fluoroprednisolone, dexamethasone, Dexamethasonum, Desamethasone, Dexamethasone [endocrine use], DEXAMETHASONE, Dexamethasone [endocrine use] (product), dexamethasone (medication), Dexamethasone [Chemical/Ingredient], dexamethasone (DMX), Dexamethasone preparation, Dexamethasone (substance), Dexamethasone preparation (product), DXM, DM, Dexamethasone (product), Dexamethasone [endocrine use] (substance), Dexamethasone preparation (substance)
Swedish Dexametason
Czech dexamethason
Finnish Deksametasoni
Russian DEKSAMETAZON, GEKSADEKADROL, ГЕКСАДЕКАДРОЛ, ДЕКСАМЕТАЗОН
Spanish dexametasona (uso endocrino) (producto), dexametasona (uso endocrino), preparado con dexametasona (producto), dexametasona (producto), preparado con dexametasona, dexametasona (sustancia), dexametasona, preparado de dexametasona (producto), preparado de dexametasona (sustancia), preparado de dexametasona, Dexametasona, Hexadecadrol
Japanese コルソン, デキサA, デキサメサゾン, ダブM, デカドロン, ビスオDS, ミタゾーン, オイラゾンD, デカドロンN, デキサ・チョーセイ, デキサ・ママレット, デキサメ, ヘキサデカドロール, デルゾン, サンテゾーン, デキサルチン, フルメプレドニゾロン, マキシデックス, デキサメタゾン, エースミン
Italian Metil-fluoro-prednisolone, Esadecadrol, Desametasone
Croatian DEKSAMETAZON
Polish Deksametazon
French Dexaméthasone
German Dexamethason, Hexadecadrol
Portuguese Dexametasona, Hexadecadrol

Ontology: Hydrocortisone (C0020268)

Definition (NCI) A hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps the body use glucose (a sugar), protein, and fats. Cortisol made in the laboratory is called hydrocortisone. It is used to treat many conditions, including inflammation, allergies, and some cancers. Cortisol is a type of glucocorticoid hormone.
Definition (MSH) The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Definition (CSP) main glucocorticoid secreted by the adrenal cortex; its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Definition (NCI) A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04)
Definition (NCI) A drug used to relieve the symptoms of certain hormone shortages and to suppress an immune response.
Definition (PDQ) A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39274&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39274&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C555" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance(T121) , Hormone(T125)
MSH D006854
SnomedCT 396458002, 56423005, 16602005
English Compound F, Cortisol, Hydrocortisone, Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, Dihydrocortisone, (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione, hydrocortisone, Cortisol (substance), Domolene, Therapeutic Hydrocortisone, hydrocortisone (medication), 17-hydroxycorticosterone, HYDROCORTISONE, Hydrocortisone [Chemical/Ingredient], cortisols, hydrocortisones, Compound F preparation, Cortisol preparation, Cortisol product, HC - Hydrocortisone, Hydrocortisone preparation, Hydrocortisone product, Hydrocortisone (substance), Hydrocortisone preparation (product), cortisol, HC, Hydrocortisone preparation (substance)
Swedish Hydrokortison
Spanish cortisol, cortisol (sustancia), preparado con hidrocortisona (producto), hidrocortisona (producto), preparado con hidrocortisona, hidrocortisona (sustancia), hidrocortisona, preparado de hidrocortisona (producto), preparado de hidrocortisona (sustancia), preparado de hidrocortisona, Cortisol, Hidrocortisona
Czech hydrokortison, kortisol, kortizol, hydrokortizon
Finnish Kortisoli
Russian KORTIZOL, GIDROKORTIZON, ГИДРОКОРТИЗОН, КОРТИЗОЛ
Japanese コルチソール, ヒドロコルチゾン, コルチソル, 17-ヒドロキシコルチコステロン, ハイドロコルチゾン, コートリル, コルチゾール
Italian Cortisolo, Idrocortisone
Croatian HIDROKORTIZON
Polish Hydrokortyzon, Kortyzol
French Cortisol, Hydrocortisone
German Cortisol, Hydrocortison, Kortisol
Portuguese Cortisol, Hidrocortisona

Ontology: Methylprednisolone (C0025815)

Definition (CHV) a kind of steroidal anti-inflammatory drugs
Definition (MSH) A PREDNISOLONE derivative with similar anti-inflammatory action.
Definition (CSP) synthetic glucocorticoid derived from progesterone, used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant.
Definition (NCI) A corticosteroid hormone replacement.
Definition (NCI) A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
Definition (PDQ) A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41528&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41528&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C647" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance(T121) , Hormone(T125)
MSH D008775
SnomedCT 325387001, 116593003, 27242001
English 6 Methylprednisolone, 6-Methylprednisolone, Methylprednisolone, Metipred, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-, Methylprednisolone [endoc], 6Alpha-Methylprednisolone, (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione, methylprednisolone, Methylprednisolonum, Methylprednisolone [endocrine use], Methylprednisolone [endocrine use] (product), methylprednisolone (medication), METHYLPREDNISOLONE, Methylprednisolone [Chemical/Ingredient], methylPREDNISolone, 6-alpha-Methylprednisolone preparation, Methylprednisolone preparation, Methylprednisolone (substance), Methylprednisolone preparation (product), MePRDL, Methylprednisolone [endocrine use] (substance), Methylprednisolone preparation (substance), MethylPREDNISolone
Swedish Metylprednisolon
Czech methylprednisolon
Finnish Metyyliprednisoloni
Russian METILPREDNIZOLON, METIPRED, URBAZON, МЕТИЛПРЕДНИЗОЛОН, МЕТИПРЕД, УРБАЗОН
Spanish metilprednisolona (uso endocrino) (producto), metilprednisolona (uso endocrino), preparado con 6-alfa-metilprednisolona, preparado con metilprednisolona (producto), metilprednisolona (producto), preparado con metilprednisolona, metilprednisolona (sustancia), metilprednisolona, preparado de 6-alfa-metilprednisolona, preparado de metilprednisolona (producto), preparado de metilprednisolona (sustancia), preparado de metilprednisolona, Metilprednisolona
Japanese メドロール, メチルプレドニゾロン, メチルプレドニソロン, ウルバソン
French 6-Méthylprednisolone, Méthylprednisolone
Croatian METILPREDNISOLON
Polish Metyloprednizolon
German Methylprednisolon
Italian Metilprednisolone
Portuguese Metilprednisolona

Ontology: prednisolone (C0032950)

Definition (NCI) A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid.
Definition (MSH) A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Definition (CSP) synthetic glucocorticoid with the general properties of the corticosteroids.
Definition (NCI) A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)
Definition (PDQ) A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C769" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance(T121)
MSH D011239
SnomedCT 325425005, 317418003, 116601002, 52388000
English Prednisolone, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, Prednisolone [for preparations see rectal prednisolone], Prednisolone [see rectal pred], .delta.1-Hydrocortisone, 1,2-Dehydrohydrocortisone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, Metacortandralone, Delta(1)Hydrocortisone, Delta-F, Delta1-dehydro-hydrocortisone, Prednisolonum, Prednisolone [endocrine use], Prednisolone [for preparations see rectal prednisolone] (product), Prednisolone [endocrine use] (product), prednisolone (medication), PREDNISOLONE, Prednisolone [Chemical/Ingredient], prednisoLONE, Deltahydrocortisone, Deltahydrocortisone preparation, Metacortandralone preparation, Prednisolone preparation, Prednisolone product, Prednisolone (substance), Prednisolone preparation (product), PRDL, Prednisolone [endocrine use] (substance), Prednisolone [for preparations see rectal prednisolone] (substance), Prednisolone preparation (substance), prednisolone, PrednisoLONE
Swedish Prednisolon
Czech prednisolon, depersolon
Finnish Prednisoloni
Russian DEPERZOLON, PREDNIZOLON, ДЕПЕРЗОЛОН, ПРЕДНИЗОЛОН
Spanish prednisolona (para preparaciones ver prednisolona rectal) (producto), prednisolona (uso endocrino) (producto), prednisolona (para preparaciones ver prednisolona rectal), prednisolona (uso endocrino), preparado con metacortandralona, preparado con prednisolona (producto), prednisolona (producto), preparado con deltahidrocortisona, preparado con prednisolona, prednisolona (sustancia), prednisolona, preparado de deltahidrocortisona, preparado de metacortandralona, preparado de prednisolona (producto), preparado de prednisolona (sustancia), preparado de prednisolona, Prednisolona
Japanese プレドニソロン, デルポPD, ドニソロン, プレドニン, シエリゾロン, プレドニゾロン
Croatian PREDNIZOLON
Polish Encortolon, Prednizolon
French Prednisolone
German Prednisolon
Italian Prednisolone
Portuguese Prednisolona