Human Immunodeficiency Virus Book

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Nevirapine

Aka: Nevirapine, Viramune, NVP
  1. See Also
    1. Anti-Retroviral Therapy
    2. Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
  2. Class
    1. Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
  3. Efficacy
    1. Good benefit in combination with 2 nucleosides
  4. Dosing
    1. Start: 200 mg PO qd for 14 days
    2. If no rash, increase dose to 200 mg PO bid
  5. Adverse effects
    1. See NNRTI for class related adverse effects
    2. Severe hepatoxicity and liver failure risk if pre-treatment CD4 >250 in men or >400 in women
  6. References
    1. (2009) Treat Guidel Med Lett 7(78): 11-22

Nevirapine (C0132326)

Definition (MSH) A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS.
Definition (CSP) potent, non-nucleoside reverse transcriptase inhibitor used, usually in combination with nucleoside analogs, for treatment of HIV infection and AIDS.
Definition (NCI) A synthetic, non-nucleoside reverse transcriptase (RT) inhibitor with antiviral properties. Nevirapine binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS. (NCI04)
Concepts Nucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
MSH D019829
SnomedCT 108704001, 386898005
English nevirapine, 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-, Nevirapine, nevirapine (medication), Nevirapine [Chemical/Ingredient], NEVIRAPINE, Nevirapine (product), Nevirapine (substance)
Swedish Nevirapin
Czech nevirapin
Finnish Nevirapiini
Russian NEVIRAPIN, НЕВИРАПИН
Japanese ネビラピン
Polish Newirapina
Spanish nevirapina (producto), nevirapina (sustancia), nevirapina, Nevirapina
French Névirapine
German Nevirapin
Italian Nevirapina
Portuguese Nevirapina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Viramune (C0728726)

Concepts Nucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
MSH D019829
English viramune, Viramune, Cahill May Roberts Brand of Nevirapine, Promeco Brand of Nevirapine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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