Human Immunodeficiency Virus Book

http://www.fpnotebook.com/

NevirapineAka: Viramune

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  1. Class
    1. Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
  2. Efficacy
    1. Good benefit in combination with 2 nucleosides
  3. Dosing
    1. Start: 200 mg PO qd for 14 days
    2. If no rash, increase dose to 200 mg PO bid
  4. Adverse effects
    1. Severe cutaneous reactions
      1. See NNRTI for complete description and approach

Nevirapine (C0132326)

Definition (CSP)potent, non-nucleoside reverse transcriptase inhibitor used, usually in combination with nucleoside analogs, for treatment of HIV infection and AIDS.
Definition (MSH)A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS.
Definition (NCI)A synthetic, non-nucleoside reverse transcriptase (RT) inhibitor with antiviral properties. Nevirapine binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS. (NCI04)
ConceptsNucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
MSHD019829
EnglishNevirapine, NEVIRAPINE PREPARATION
Spanishnevirapina
Parent ConceptsReverse Transcriptase Inhibitors (C0282519), Pyridines (C0034255), Antiviral Agents (C0003451), Drug allergen (C1320237), Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors (C1579420)
SourcesCSP, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Viramune (C0728726)

ConceptsNucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
MSHD019829
EnglishCahill May Roberts Brand of Nevirapine, Promeco Brand of Nevirapine, Viramune
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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