A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. It is a type of systemic antiviral.
Definition (MSH)
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Definition (NCI)
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04)
Definition (CSP)
synthetic thymidine analog that inhibits replication of some retroviruses, including human immunodeficiency virus; used in the management of AIDS or HIV infection.
Definition (PDQ)
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40121&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40121&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C947" NCI Thesaurus)
Concepts
Nucleic Acid, Nucleoside, or Nucleotide (T114)
, Pharmacologic Substance (T121)
MSH
D015215
SnomedCT
27479000, 387151007
English
3' Azido 2',3' Dideoxythymidine, 3'-Azido-2',3'-Dideoxythymidine, Antiviral AZT, Azidothymidine, AZT (Antiviral), AZT Antiviral, AZT, Antiviral, Zidovudine, zidovudine, Thymidine, 3'-azido-3'-deoxy-, 3' Azido 3' deoxythymidine, 3'-Azido-3'-deoxythymidine, 3'-azido-3'-deoxythymidine, azidodeoxythymidine, ZIDOVUDINE, azidothymidine (AZT) (medication), azidothymidine (AZT), Zidovudine [Chemical/Ingredient], azt, zdv, compound s, zidovudine (AZT), s compound, AZT, AZT - Azidothymidine, Zidovudine product, Zidovudine (product), Zidovudine (substance), azidothymidine, ZDV
German
Azidothymidin, 3-Azido-2,3-Dideoxythymidin, 3'-Azido-2',3'-Dideoxythymidin, AZT (Antiviral), AZT, antiviral, 3'-Azido-3'-Deoxythymidin, AZT (Antivirusmittel), 3-Azido-3-Deoxythymidin, Zidovudin
Swedish
Zidovudin
Czech
azidothymidin, zidovudin
Finnish
Tsidovudiini
Russian
AZIDOTIMIDIN, ZIDOVUDIN, AZT (ANTIVIRUSNYI), AZT (АНТИВИРУСНЫЙ), АЗИДОТИМИДИН, ЗИДОВУДИН