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Chloroquine
- Indications: Malaria Prophylaxis
- Areas without chloroquine resistance
- Pediatric and Obstetric patients
- Prophylactic Dosing
- Adult: 300 mg base (500 mg salt) PO once weekly
- Pediatrics
- Dose: 5 mg/kg base (8.3 mg/kg salt) PO once weekly
- Maximum dose: 300 mg base per week
- Directions
- Taking with food decreases gastric irritation
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| Definition (MSH) | The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. |
| Definition (CSP) | antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus. |
| Definition (NCI) | A synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Chingamin, Chlorochin, Chloroquine, CHLOROQUINE PREPARATION, Khingamin |
| Spanish | cloroquina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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