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Chloroquine
Aka: Chloroquine- Indications: Malaria Prophylaxis
- Areas without Chloroquine resistance
- Pediatric and Obstetric patients
- Prophylactic Dosing
- Adult: 300 mg base (500 mg salt) PO once weekly
- Pediatrics
- Dose: 5 mg/kg base (8.3 mg/kg salt) PO once weekly
- Maximum dose: 300 mg base per week
- Directions
- Taking with food decreases gastric irritation
Chloroquine (C0008269) |
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| Definition (NCI) | A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. |
| Definition (MSH) | The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. |
| Definition (CSP) | antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D002738 |
| SnomedCT | 324890009, 330034001, 14728000, 373468005 |
| English | Chingamin, Chlorochin, Chloroquine, Khingamin, chloroquine, 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Chloroquine [anti-malarial], Chloroquine [musculo-skeletal], Chloroquine [anti-malarial] (product), Chloroquine [musculo-skeletal] (product), chloroquine (medication), Chloroquine [Chemical/Ingredient], chloroquine products, Chloroquine (product), Chloroquine (substance), Chloroquine [anti-malarial] (substance), Chloroquine [musculo-skeletal] (substance), CHLOROQUINE |
| Swedish | Klorokin |
| Czech | chlorochin |
| Finnish | Klorokiini |
| Russian | KHLOROKHIN, KHINGAMIN, ХИНГАМИН, ХЛОРОХИН |
| Spanish | cloroquina [uso musculoesquelético] (producto), cloroquina [antipalúdico], cloroquina [uso musculoesquelético], cloroquina [antipalúdico] (producto), cloroquina (producto), cloroquina (sustancia), cloroquina, Cloroquina |
| Japanese | リン酸クロロキン, クロロキン |
| Polish | Arechina, Resochina, Chlorochina |
| French | Chloroquine |
| German | Chlorochin |
| Italian | Clorochina |
| Portuguese | Cloroquina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |