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Nephrotic SyndromeAka: Nephrosis
- Epidemiology
- Uncommon
- Etiology
- Primary glomerulonephropathy progresses to Nephrosis
- Occurs in 20% of cases
- Children
- Minimal Change Disease (NIL Lesion)
- Adults
- Membranous Nephropathy (50%)
- Minimal Change Disease (25%)
- Focal Glomerulosclerosis (15%)
- Other
- Systemic Lupus Erythematosus
- Membranoproliferative Glomerulonephritis (MPGN)
- IgA Nephropathy
- Diabetic glomerulosclerosis
- Amyloidosis
- Goodpasture's Syndrome
- Hodgkin's Lymphoma
- Preeclampsia or Eclampsia
- Drugs
- Penicillamine
- Gold
- Infection (includes PSGN)
- Primary glomerulonephropathy progresses to Nephrosis
- Signs and Symptoms
- Edema
- Hypoalbuminemia
- Hyperalbuminuria (Proteinuria >3.5 grams per day)
- Hypertension
- Hyperlipidemia
- Renal Insufficiency
- Management
- Consult with nephrology
- Indentify underlying cause
- Prevention of progression
- ACE Inhibitor or Angiotensin Receptor Blocker
- Consider Spironolactone
- Stop offending medications
- Maintain Blood Pressure less than 130/80
- Control Hyperlipidemia
Nephrosis (C0027720) | |
|---|---|
| Definition (MSH) | Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. |
| Definition (CSP) | diseases of the kidney characterized by purely degenerative lesions of the renal tubules without an inflammatory component. |
| Concepts | Disease or Syndrome (T047) |
| ICD9 | 581.9 |
| MSH | D009401 |
| English | Nephroses, Nephrosis |
| Spanish | nefrosis |
| Parent Concepts | Kidney Diseases (C0022658), Hypoproteinemia (C0020639), Nephrosis (C0027720), kidney morphologic (C0549592) |
| Sources | AOD, COSTAR, CSP, CST, MSH, MTHICD9, NDFRT, OMIM, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
Nephrotic Syndrome (C0027726) | |
|---|---|
| Definition (MSH) | A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. |
| Definition (AIR) | Nephrotic Syndrome: twenty-four hour urine protein > three grams. May be associated with hypoalbuminemia and hypercholesterolemia. |
| Definition (CSP) | diseases involving defective kidney glomeruli, characterized by massive proteinuria and lipiduria with varying degrees of edema, hypoalbuminemia, and hyperlipidemia. |
| Concepts | Disease or Syndrome (T047) |
| ICD9 | 581, V13.03 |
| MSH | D009404 |
| English | NEPHROTIC SYNDROME, Nephrotic Syndromes, NS - Nephrotic syndrome, PERSONL HX NEPHROTIC SYN, SYNDROME NEPHROTIC |
| Spanish | sindrome nefrotico |
| Parent Concepts | Renal findings, including biopsy (C0150937), Kidney finding (C0426703), Kidney Diseases (C0022658), Nephrosis (C0027720), Syndrome (C0039082), Nephritis, nephrosis and nephrotic syndrome NOS (C0178287), [V]Personal history of urinary system disorder (C0700516), Non-Neoplastic Renal Disorder (C1335036), Nephrotic Syndrome (C0027726), Duplicate concept (C1274013) |
| Sources | AIR, AOD, COSTAR, CSP, CST, DXP, ICD9CM, LCH, MSH, MTH, NCI, NDFRT, OMIM, QMR, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
