Nephrology Book

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Nephrotic SyndromeAka: Nephrosis

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  1. Epidemiology
    1. Uncommon
  2. Etiology
    1. Primary glomerulonephropathy progresses to Nephrosis
      1. Occurs in 20% of cases
    2. Children
      1. Minimal Change Disease (NIL Lesion)
    3. Adults
      1. Membranous Nephropathy (50%)
      2. Minimal Change Disease (25%)
      3. Focal Glomerulosclerosis (15%)
      4. Other
        1. Systemic Lupus Erythematosus
        2. Membranoproliferative Glomerulonephritis (MPGN)
        3. IgA Nephropathy
        4. Diabetic glomerulosclerosis
        5. Amyloidosis
        6. Goodpasture's Syndrome
        7. Hodgkin's Lymphoma
        8. Preeclampsia or Eclampsia
        9. Drugs
          1. Penicillamine
          2. Gold
        10. Infection (includes PSGN)
  3. Signs and Symptoms
    1. Edema
    2. Hypoalbuminemia
    3. Hyperalbuminuria (Proteinuria >3.5 grams per day)
    4. Hypertension
    5. Hyperlipidemia
    6. Renal Insufficiency
  4. Management
    1. Symptomatic
      1. Protein restriction
      2. Fluid restriction
      3. Diuretics
        1. Thiazide Diuretic
        2. Loop Diuretic
    2. Prednisone
    3. Cytotoxic agents

Nephrosis (C0027720)

Definition (MSH)Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.
Definition (CSP)diseases of the kidney characterized by purely degenerative lesions of the renal tubules without an inflammatory component.
ConceptsDisease or Syndrome (T047)
ICD9581.9
EnglishNephroses, Nephrosis
Spanishnefrosis
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Nephrotic Syndrome (C0027726)

Definition (MSH)A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Definition (AIR)Nephrotic Syndrome: twenty-four hour urine protein > three grams. May be associated with hypoalbuminemia and hypercholesterolemia.
Definition (CSP)diseases involving defective kidney glomeruli, characterized by massive proteinuria and lipiduria with varying degrees of edema, hypoalbuminemia, and hyperlipidemia.
ConceptsDisease or Syndrome (T047)
ICD9581, V13.03
EnglishNEPHROTIC SYNDROME, Nephrotic Syndromes, PERSONL HX NEPHROTIC SYN, SYNDROME NEPHROTIC
Spanishsíndrome nefrótico, sindrome nefrotico
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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