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Goodpasture's Syndrome

Pathophysiology
1. Antibody to renal and alveolar basement membrane
  1. Intraalveolar hemorrhage
  2. Glomerulonephritis
Symptoms and Signs
1. Pulmonary
  1. Hemoptysis
  2. Cough
  3. Exertional Dyspnea
  4. Rales and rhonchi on lung exam
2. Renal
  1. Glomerulonephritis
Labs
1. Basement Membrane Antibody (anti-GBM) present
2. Complete Blood Count
  1. Normochromic Anemia
3. Gastric aspirate or Bloody Sputum exam
  1. Siderophages
4. Urinalysis
  1. Consistent with Glomerulonephritis
Imaging: Chest XRay
1. Bilateral perihilar patchy infiltrates
Diagnosis
1. Renal Biopsy
  1. Linear Immunofluorescence
2. Lung Biopsy
  1. Linear IgG
Course
1. Rapidly Progressive Glomerulonephritis is typical
2. Renal Failure usually ensues
Management
1. Plasma exchange
2. Glucocorticoids IV for severe lung hemorrhage

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.