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ImmunoglobulinAka: Antibody, Monoclonal Antibody, Fragment Antigen Binding, Fragment Crystallizable, Ligand
- Definitions
- Fragment Antigen Binding (Fab)
- Antibody region that recognizes and binds antigens
- Fragment crystallizable (Fc)
- Antibody region that interacts with immune system components
- Endogenous Fc triggers Natural Killer Cells and complement cascade
- Synthetic monoclonal antibodies may bind Fc to toxins or radioisotopes in Chemotherapy
- Ligand
- Molecule that binds to a specific receptor
- Monoclonal Antibody
- Identical antibodies that are synthesized by a single immune cell type
- Synthesized in labs to be targeted at disease-specific molecules
- Fragment Antigen Binding (Fab)
- Physiology: Immunoglobulin
- Structure: Immunoglobulin is composed of a 4 chain monomeric structure
- Two heavy chains (identical)
- Five heavy chain classes: M, D, E, A, and G1-4
- Two light chains (identical)
- Two light chain classes: kappa and lambda
- Two heavy chains (identical)
- Structure: Immunoglobulin is composed of a 4 chain monomeric structure
- Types: Immunoglobulins
- References
- Bakerman (1984) ABCs of Interpretive Lab Data, p. 392
Antibodies (C0003241) | |
|---|---|
| Definition (MSH) | Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). |
| Definition (CSP) | infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms such as bacteria or viruses and toxins; they are generally known as immunoglobulins, and are made and secreted by B-lymphocytes in response to stimulation by antigens; each specific antibody binds only to the specific antigen that stimulated its production. |
| Definition (NCI) | (AN-tih-BOD-ee) A type of protein made by certain white blood cells in response to a foreign substance (antigen). Each antibody can bind to only a specific antigen. The purpose of this binding is to help destroy the antigen. Antibodies can work in several ways, depending on the nature of the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen. |
| Definition (NCI) | An antibody is a type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| MSH | D000906 |
| English | Ab, Antibodies, Antibody, Unidentified Ab, Unidentified Antibody |
| Spanish | anticuerpo |
| Parent Concepts | Immunologic Factors (C0021054), Immunology (C0152036), Immunoglobulins (C0021027), Immunoproteins (C0021072), Proteins (C0033684) |
| Sources | AOD, CSP, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT, UWDA Derived from the NIH UMLS (Unified Medical Language System) |
Ligands (C0023688) | |
|---|---|
| Definition (MSH) | A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed) |
| Definition (CSP) | molecule that binds to another molecule, especially a small molecule that binds specifically to a larger molecule. |
| Concepts | Chemical (T103) |
| MSH | D008024 |
| English | ligand, Ligands |
| Parent Concepts | chemical bonding, molecular interaction (C0678593), chemical binding (C0178542), Laboratory Chemicals (C0525067) |
| Sources | AOD, CSP, LCH, MSH, MTH Derived from the NIH UMLS (Unified Medical Language System) |
