Infectious Disease Book

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Immunoglobulin MAka: IgM Immunoglobulin, Gamma Globulin M, IgM

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  1. Normal
    1. Range: 45-150 mg/dl
    2. Varies by age
  2. Increased
    1. Liver disease
      1. Primary biliary Cirrhosis
      2. Early hepatitis
    2. Waldenstrom's Macroglobulinemia
    3. Infection
      1. Brucellosis
      2. Malaria
      3. Trypanosomiasis
      4. Toxoplasmosis
  3. Decreased
    1. Hypo-IgM
    2. Protein-losing Enteropathy

Immunoglobulin M (C0020861)

Definition (CSP)pentameric immunoglobulin largely confined to the intravascular pool and the predominant early antibody frequently seen in the immune response to antigenically complex infectious organisms.
Definition (MSH)A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Definition (NCI)The major immunoglobulin secreted during a primary immune response. IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers.
ConceptsAmino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSHD007075
English19S Gamma Globulin, IgM, IgM - Immunoglobulin M, Immunoglobulin IgM, Immunoglobulin M
Spanishinmunoglobulina IgM
Parent ConceptsImmunoglobulins (C0021027), Immunoglobulin Isotypes (C0021017), Duplicate concept (C1274013)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT, UWDA
Derived from the NIH UMLS (Unified Medical Language System)



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