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Brucellosis

Aka: Brucellosis, Brucella abortus, Brucella suis, Brucella melitensis
  1. Epidemiology
    1. US Incidence <100 cases per year (0.34/100,000)
  2. Etiology
    1. Brucella abortus
    2. Brucella suis
    3. Brucella melitensis
  3. Pathophysiology
    1. Facultative intracellular parasite
      1. Releases endotoxin when dies
    2. Infective dose: 10-100 organisms
    3. Incubation: 5-60 days
  4. Transmission
    1. Infected animal products
      1. Tissue from Sheep in U.S.
      2. Unpasteurized milk
    2. Vaccine exposure
    3. No transmission person to person
    4. Enters via mucus membranes, broken skin, or inhalation
  5. Risk Factors
    1. Veterinarians
    2. Farm workers
    3. Meat processing plants
    4. Travel or residence in endemic region
      1. Mediterranean
      2. India
      3. North Africa, East Africa
      4. Central Asia, South Asia
  6. Symptoms
    1. Intermittent Fevers
      1. Undulating fever
      2. Temperature peaks in evening to 101-104
    2. Arthralgia (90%)
    3. Weakness
    4. Lassitude
    5. Weight loss
    6. Headache
    7. Sweating
    8. Chills
  7. Signs
    1. Hepatosplenomegaly (20-30%)
    2. Cervical or Inguinal Lymphadenopathy (12-20%)
    3. Orchitis or Epididymitis (2-40%)
    4. Purpura (5%)
  8. Differential Diagnosis
    1. Tularemia
    2. Psittacosis
    3. Rickettsia
    4. Visceral Leishmaniasis
    5. Human Immunodeficiency Virus (HIV)
  9. Labs
    1. Culture (Slow growing, fastidious organism)
      1. Blood Culture (70% sensitive in acute illness)
      2. Discharge Culture
      3. Bone Marrow Aspirate (90% sensitive in acute illness)
    2. Complete Blood Count
      1. Thrombocytopenia
      2. Granulopenia
      3. Lymphopenia or Lymphocytosis
      4. Anemia
    3. Brucella Serology
    4. Liver Function Tests (elevated in 30-60%)
    5. Bone Marrow Biopsy show granuloma
  10. Course
    1. Weeks to months
  11. Prognosis
    1. Case Fatality <5% treated
  12. References
    1. (1998) Medical Management of Biological Casualties
      1. U.S. Army Medical Research Institute of ID

Brucella suis bacterium (C0300960)

Definition (NCI) Any bacterial organism that can be assigned to the species Brucella suis.
Definition (MSH) A species of gram-negative bacteria, primarily infecting SWINE, but it can also infect humans, DOGS, and HARES.
Concepts Bacterium (T007)
MSH D041021
SnomedCT 48317004, 186307004
English Brucella suis, Brucella suis bacterium, Brucella melitensis bv. Suis, rucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980) emend. Verger et al. 1985, biovar Suis, Brucella suis Huddleson 1929 (Approved Lists 1980), BRUCELLA SUIS, Brucella melitensis biovar suis, Brucella melitensis biov suis, Brucella suis (organism)
French Brucella melitensis biovar suis, Brucella suis
Japanese ブタ流産菌ブルセラ症, ﾌﾞﾀﾘｭｳｻﾞﾝｷﾝﾌﾞﾙｾﾗｼｮｳ
Swedish Brucella suis
Czech Brucella suis
Finnish Brucella suis
Italian Brucella melitensis biovar suis, Brucella suis
Polish Brucella suis
Hungarian Brucella suis
Spanish Brucella melitensis, biovariedad suis, Brucella suis (organismo), Brucella suis
German Brucella suis
Russian BRUCELLA SUIS
Dutch Brucella suis
Portuguese Brucella suis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Brucella melitensis bacterium (C0006305)

Definition (NCI) Any bacterial organism that can be assigned to the species Brucella melitensis.
Definition (MSH) A species of the genus BRUCELLA whose natural hosts are sheep and goats. Other mammals, including humans, may be infected. In general, these organisms tend to be more virulent for laboratory animals than BRUCELLA ABORTUS and may cause fatal infections.
Concepts Bacterium (T007)
MSH D017347
SnomedCT 72829003
English Brucella melitensis, Brucella melitensis bacterium, BRUCELLA MELITENSIS, Brucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980) emend. Verger et al. 1985, Brucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980), Streptococcus Miletensis, Micrococcus melitensis, Brucella melitensis (organism)
Japanese マルタ熱菌, ﾏﾙﾀﾈﾂｷﾝ
Swedish Brucella melitensis
Czech Brucella melitensis
Finnish Brucella melitensis
Spanish Micrococcus melitensis, Brucella melitensis (organismo), Brucella melitensis
Portuguese Micrococcus melitensis, Brucella melitensis
Polish Brucella melitensis
Hungarian Brucella melitensis
French Brucella melitensis
German Bacterium melitensis, Brucella melitensis, Maltafieber-Bakterium
Italian Brucella melitensis
Russian BRUCELLA MELITENSIS
Dutch Brucella melitensis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Brucellosis (C0006309)

Definition (MSHFRE) Infection provoquée par des bactéries du genre Brucella impliquant surtout le système réticulo-endothélial. Maladie caractérisée par fièvre, affaiblissement, malaise et amaigrissement.
Definition (NCI) A gram negative bacterial infection caused by bacteria of the genus Brucella. Humans are infected by ingesting unpasteurized milk or meat from infected animals. Signs and symptoms include fevers, sweating, weakness, headache, muscle pain, arthritis and anemia.
Definition (MSH) Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Concepts Disease or Syndrome (T047)
MSH D002006
ICD9 023.9, 023
ICD10 A23, A23.9
SnomedCT 111804008, 154296006, 187304000, 186310006, 75702008
English Brucelloses, Fevers, Undulant, Malta Fever, Undulant Fever, Undulant Fevers, Fever, Malta, BRUCELLOSIS, FEVER, MALTA, FEVER, MEDITERRANEAN, FEVER, UNDULANT, Fever, Undulant, MALTA FEVER, MELITOCOCCOSIS, UNDULANT FEVER, Brucellosis, NOS, Brucellosis NOS, Brucellosis, unspecified, [X]Brucellosis, unspecified, Brucellosis due to Brucella sp., Brucellosis due to Brucella sp. (disorder), brucellosis (diagnosis), brucellosis, E-114 BRUCELLOSIS, Brucella infections, Unspecified brucellosis, MEDITERRANEAN FEVER, [X]Brucellosis, unspecified (disorder), Brucellosis due to Brucella species (disorder), Brucellosis due to Brucella species, Brucellosis NOS (disorder), undulant fever, Brucellosis [Disease/Finding], mediterranean fever, rock fever, cyprus fever, brucelloses, brucellosi, brucellose, fever mediterranean, malta fever, brucellosys, fever malta, Fever, Gibraltar, Cyprus Fever, Fevers, Rock, Gibraltar Fever, Fever, Cyprus, Fever, Rock, Cyprus Fevers, Fevers, Cyprus, Rock Fever, Rock Fevers, Malta fever, Undulant fever, Mediterranean fever, Brucellosis (disorder), Cyprus fever, Gibraltar fever, Rock fever, Gibraltar; fever, Malta; fever, fever; Cyprus, fever; Gibraltar, fever; Malta, infection; Brucella, Brucella; infection, Bruce, Brucellosis
Italian Infezioni da brucella, Brucellosi non specificata, Febbre mediterranea, Febbre maltese, Febbre ondulante, Brucellosi
Dutch niet-gespecificeerde brucellose, mediterrane koorts, brucellose, niet-gespecificeerd, Brucella; infectie, Gibraltar; koorts, Malta; koorts, infectie; Brucella, koorts; Cyprus, koorts; Gibraltar, koorts; Malta, Brucellose, niet gespecificeerd, Brucella-infecties, brucellose, Brucellose, Brucellosis, Febris undulans, Malta-koorts
French Brucellose non précisée, Brucellose, non précisée, Infections à Brucella, Brucellose, Fièvre méditerranéenne, Fièvre ondulante, Mélitococcie, Fièvre de Malte
German unspezifische Brucellose, Brucellose, unspezifisch, Mittelmeerfieber, Malta-Fieber, Brucellose, nicht naeher bezeichnet, Brucella-Infektionen, Brucellose, Febris undulans, Maltafieber
Portuguese Febre mediterrânica, Febre ondulante, Brucelose NE, Infecções a Brucella, Brucelose, Febre de Malta, Febre Ondulante
Spanish Fiebre mediterránea, Fiebre ondulante, Brucelosis no especificada, Brucellosis, [X]brucelosis, no especificada, [X]brucelosis, no especificada (trastorno), brucelosis causada por especies de Brucella (trastorno), brucelosis causada por especies de Brucella, brucelosis (trastorno), brucelosis, SAI (trastorno), brucelosis, SAI, brucelosis, fiebre de Malta, fiebre del Mediterráneo, fiebre mediterránea, fiebre ondulante, Infecciones por brucella, Brucelosis, Fiebre de Malta, Fiebre Ondulante
Japanese ブルセラ症、詳細不明, 詳細不明のブルセラ症, ブルセラ感染, ﾌﾞﾙｾﾗｼｮｳ, ﾌﾞﾙｾﾗｼｮｳｼｮｳｻｲﾌﾒｲ, ﾌﾞﾙｾﾗｶﾝｾﾝ, ﾁﾁｭｳｶｲﾈﾂ, ﾊｼﾞｮｳﾈﾂ, ｼｮｳｻｲﾌﾒｲﾉﾌﾞﾙｾﾗｼｮｳ, ﾏﾙﾀﾈﾂ, ブルセラ症, 地中海熱, マルタ熱, 波状熱
Swedish Brucellos
Czech brucelóza, Brucelózy, Febris undulans, Blíže neurčená brucelóza, Brucelóza, Brucelóza, blíže neurčená, Maltská horečka, Středozemní horečka
Finnish Bruselloosi
Russian BRUTSELLEZ, UNDULIRUIUSHCHAIA LIKHORADKA, MAL'TIISKAIA LIKHORADKA, SREDIZEMNOMORSKAIA LIKHORADKA, VOLNOOBRAZNAIA LIKHORADKA, БРУЦЕЛЛЕЗ, ВОЛНООБРАЗНАЯ ЛИХОРАДКА, МАЛЬТИЙСКАЯ ЛИХОРАДКА, СРЕДИЗЕМНОМОРСКАЯ ЛИХОРАДКА, УНДУЛИРУЮЩАЯ ЛИХОРАДКА
Korean 브루셀라증, 상세불명의 브루셀라증
Polish Gorączka śródziemnomorska, Gorączka falista, Bruceloza, Gorączka maltańska
Hungarian Brucella fertőzések, brucellosis, nem meghatározott, Mediterrán láz, nem meghatározott brucellosis, Febris undulans, Brucellosis, Máltai láz
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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