Infectious Disease Book

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Immunoglobulin GAka: IgG Immunoglobulin, Gamma Globulin G, IgG

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  1. Normal
    1. Range: 800-1500 mg/dl
    2. Varies by age
  2. Physiology
    1. Crosses maternal-fetal membrane
    2. Interacts with complement system
    3. Enhances phagocytosis by binding Macrophages and PMNs
    4. Enhance cytotoxicity by binding Natural Killer Cells
  3. Decreased
    1. Hypo-IgG
    2. Protein losing Enteropathy
    3. Nephrotic Syndrome
  4. Increased
    1. Chronic granulomatous infection
    2. Inflammation
    3. Multiple Myeloma
    4. Liver disease
    5. Infections
    6. Autoimmune disease

Immunoglobulin G (C0020852)

Definition (CSP)major immunoglobulin in normal human serum, distributed evenly between the intravascular and extravascular pools; it is the major antibody of secondary immune responses and the exclusive antitoxin class.
Definition (MSH)The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Definition (NCI)An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
English7S Gamma Globulin, GAMMA GLOBULIN 07S, IgG, Immunoglobulin G, Immunoglobulin IgG
Spanishinmunoglobulina IgG
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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