I. See Also

II. Indication

  1. Highly specific for Systemic Lupus Erythematosus

III. Normal

  1. Negative

IV. Positive (percentage refers to sensitivity)

  1. Systemic Lupus Erythematosus (60%)
    1. Associated with Lupus Nephritis
    2. Associated with Lupus CNS Involvement
    3. Correlates with disease activity
  2. Sjogren's Syndrome (5%)
  3. Rheumatoid Arthritis (<5%)
  4. Chronic active hepatitis
  5. Biliary Cirrhosis
  6. Epstein Barr Virus
  7. Cytomegalovirus

V. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed] (or open in [QxMD Read])
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed] (or open in [QxMD Read])

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