II. Indication

  1. Proteinuria evaluation and monitoring
  2. Chronic Kidney Disease diagnosis

III. Efficacy

  1. More accurate than 24 Hour Urine Protein collection
  2. Most accurate if first morning void is used
  3. Urine Albumin to Creatinine Ratio is preferred over Urine Protein to Creatinine Ratio
    1. Urine Albumin to Creatinine Ratio has higher Test Sensitivity (see below)
    2. Consider Urine Protein ratio when Urine Albumin to Creatinine Ratio is high (>300 mg/g)

IV. Technique: Random urine collection

  1. Urine Creatinine in mg
  2. Urine Protein in mg
  3. Calculate Urine Protein mg to Urine Creatinine mg Ratio

V. Interpretation: Urine Protein to Urine Creatinine Ratio

  1. Consider when Urine Albumin to Creatinine Ratio is high (>300 mg/g)
  2. Lower efficacy than Urine Albumin to Creatinine Ratio
    1. Lower Test Sensitivity than Urine Albumin to Creatinine Ratio for low level Proteinuria (<150 mg/24 hours)
    2. Also measures proteins unrelated to primary Kidney disease (e.g. Multiple Myeloma)
  3. Child under age 2 years
    1. Normal Ratio <0.5
  4. Adults and children over age 2 years
    1. Normal ratio <0.2 grams protein per gram Creatinine
    2. Nephrotic Ratio >3.5 grams protein per gram Creatinine
  5. Estimation of total protein
    1. Total protein (g/m2/day) = Upr/Cr * 0.63
    2. Abitbol (1990) J Pediatr 116(2): 243-7 [PubMed]
  6. False positive causes (unrelated to Kidney disease)
    1. Tubular secreted proteins (Tamm-Horsfall protein)
    2. Plasma Proteins (Multiple Myeloma, Infectious disease)

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Ontology: Urine protein/creatinine ratio measurement (C1096054)

Concepts Laboratory Procedure (T059)
SnomedCT 167144005, 144383004, 313500004
Italian Rapporto proteine/creatinina nelle urine
Japanese 尿中蛋白/クレアチニン比, ニョウチュウタンパククレアチニンヒ
English Urine protein/creatinine ratio measurement, urine protein : creatinine ratio, urine protein/creatinine ratio measurement (lab test), urine protein/creatinine ratio measurement, urine protein creatinine ratio, creatinine protein ratio urine, Urine protein/creatinine ratio (procedure), Urine protein/creatinine ratio, Urine protein/creatinine ratio measurement (procedure)
Czech Poměr bílkovina/kreatinin v moči
Hungarian Vizelet fehérje/kreatinin arány
Portuguese Razão de proteína/creatinina na urina
Spanish Proporción proteína-creatinina en orina, medición urinaria del índice proteínas/creatinina (procedimiento), medición urinaria del índice proteínas/creatinina, índice urinario proteínas/creatinina
Dutch urine proteïne/creatinine ratio
French Rapport protéine/créatinine de l'urine
German Protein/Creatinin Quotient im Urin