II. Indications

  1. Diabetes Mellitus
  2. Hypertension
    1. Questionable efficacy as prognostic factor in Hypertension (contrast with Diabetes Mellitus)

III. Protocol

  1. Nephropathy diagnosis needs 2 of 3 samples positive
  2. Typically performed as a Urine Albumin to Creatinine Ratio (random spot urine collection)
  3. Consider postural Proteinuria (especially in adolescents)
    1. Obtain overnight timed urine collection

IV. Interpretation: Urine Albumin

  1. Normal (or mildly increased)
    1. 24h Collection: <30 mg/day
    2. Timed Collection: <20 mcg/min
    3. Urine Albumin to Creatinine Ratio (Spot Collection): <30 mcg/mg Creatinine
  2. Microalbuminuria (moderately increased)
    1. 24h Collection: 30-300 mg/day
    2. Timed Collection: 20-200 mcg/min
    3. Urine Albumin to Creatinine Ratio (Spot Collection): 30-300 mcg/mg Creatinine
  3. Macroalbuminuria (severely increased)
    1. 24h CollecSpot Collectiontion: >300 mg/day
    2. Timed Collection: >200 mcg/min
    3. Urine Albumin to Creatinine Ratio (Spot Collection): >300 mcg/mg Creatinine

V. Interpretation: Urine Albumin to Creatinine Ratio (preferred over Urine Protein to Creatinine Ratio)

  1. Higher Test Sensitivity than Urine Protein to Urine Creatinine Ratio
  2. Normal Ratio (in general <30 mg/g is normal)
    1. Men: < 0.017 (or 17 mg albumin to 1 gram Creatinine)
    2. Women: <0.025 (or 25 mg albumin to 1 gram Creatinine)
  3. Microalbuminuria (moderately increased): 30-300 mg albumin/g Creatinine
  4. Macroalbuminuria (severely increased): >300 mg albumin/g Creatinine
  5. False positive causes
    1. Menstrual Bleeding
    2. Urinary Tract Infection
    3. Exercise

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Related Studies (from Trip Database) Open in New Window

Ontology: Urine albumin/creatinine ratio measurement (C0455271)

Concepts Laboratory Procedure (T059)
SnomedCT 144765005, 167540008, 271075006
Italian Rapporto albumina/creatinina nelle urine
Japanese 尿中アルブミン/クレアチニン比, ニョウチュウアルブミンクレアチニンヒ
Czech Poměr albumin/kreatinin v moči
English Urine albumin/creatinine ratio measurement, albumin urine creatinine ratio, urine albumin creatinine ratio, urine albumin/creatinine ratio measurement, Urine albumin:creatinine ratio (& level) (procedure), Urine albumin:creatinine ratio (& level), Urine albumin:creatinine ratio, urine albumin / creatinine ratio (lab test), urine albumin / creatinine ratio, Urine albumin/creatinine ratio, Urine albumin/creatinine ratio measurement (procedure)
Hungarian Vizelet albumin / kreatinin arány
Spanish determinación de índice urinario albúmina/creatinina, medición urinaria del índice albúmina/creatinina (procedimiento), medición urinaria del índice albúmina/creatinina, Proporción albúmina-creatinina en orina
Portuguese Razão de albumina/creatinina na urina
Dutch urine albumine/creatinine ratio
French Rapport albumine/créatinine de l'urine
German Albumin/Creatinin Quotient im Urin

Ontology: Urine microalbumin/creatinine ratio measurement (C0584615)

Concepts Laboratory Procedure (T059)
SnomedCT 271076007
English urine microalbumin/creatinine ratio, urine microalbumin/creatinine ratio (lab test), Urine microalbumin/creatinine ratio, Urine microalbumin/creatinine ratio measurement (procedure), Urine microalbumin/creatinine ratio measurement
Spanish determinación de índice urinario microalbúmina/creatinina, medición urinaria del índice microalbúmina/creatinina (procedimiento), medición urinaria del índice microalbúmina/creatinina

Ontology: Microalbuminuria (C0730345)

Concepts Disease or Syndrome (T047)
SnomedCT 312976007, 207314005, 312975006
Italian Microalbuminuria
English [D]Microalbuminuria (context-dependent category), microalbuminuria (diagnosis), microalbuminuria, [D]Microalbuminuria, Microalbuminuria, [D]Microalbuminuria (situation), Microalbuminuria (finding)
Japanese ミクロアルブミン尿, ミクロアルブミンニョウ
Spanish [D]microalbuminuria (categoría dependiente del contexto), [D]microalbuminuria (situación), [D]microalbuminuria, microalbuminuria (hallazgo), microalbuminuria, Microalbuminuria
Czech Mikroalbuminurie
Hungarian microalbuminuria
Portuguese Microalbuminúria
Dutch micro-albuminurie
French Microalbuminurie
German Mikroalbuminurie

Ontology: Microalbuminuria measurement (C0740086)

Concepts Laboratory Procedure (T059)
SnomedCT 167581000, 144806001, 46716003
CPT 82043
Dutch urine microalbumine
German Mikroalbumin im Urin
Italian Microalbumina nelle urine
Portuguese Micralbumina urinária
Spanish Microalbúmina en orina, medición de microalbuminuria (procedimiento), medición de microalbuminuria
Japanese 尿中ミクロアルブミン, ニョウチュウミクロアルブミン
French Microalbumine dans l'urine
English urine microalbumin measurement, urine microalbumin measurement (lab test), microalbumin level, urine microalbumin, microalbumin urine, Measurement of microalbumin in urine, Urine microalbumin (& level) (procedure), Urine microalbumin (& level), Urine Microalbumin Measurement, Urine microalbumin, Urine microalbumin level, Microalbuminuria measurement (procedure), Microalbuminuria measurement, NOS, Microalbuminuria measurement
Czech Mikroalbumin v moči
Hungarian Vizelet mikroalbumin

Ontology: macroalbuminuria (C1654921)

Concepts Finding (T033)
English macroalbuminuria, Macroalbuminuria