Gastroenterology Book

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Hepatitis B SerologyAka: Hepatitis B Surface Antibody, Hepatitis B Envelope Antigen, Hepatitis B Envelope Antibody, HBsAg, HBeAg, xHBsAb, xHBs IgG, xHBcAb, xHBc IgM, xHBc IgG, xHBeAb, xHBe IgM, xHBe IgG, Hepatitis B Surface Antigen, Hepatitis B Core Antibody

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  1. See Also
    1. Hepatitis B
  2. Detectable Antigens
    1. Hepatitis B Surface Antigen: HBsAg
      1. First detectable agent in acute Hepatitis B Infection
      2. Present as early as incubation period
    2. Hepatitis B Envelope Antigen: HBeAg
      1. Highly Infectious State
      2. Chronic Infection
  3. Detectable Antibodies
    1. Hepatitis B Surface Antibody: xHBsAb IgG
      1. Prior Hepatitis B Infection with Immunity
      2. Prior Hepatitis B Vaccine with Immunity
    2. Hepatitis B Core Antibody: xHBcAb IgM and IgG
      1. Covers Convalescent period
        1. Window between HBsAg clearance to xHBsAb conversion
        2. HBsAg negative during this time
    3. Hepatitis B Envelope Antibody: xHBeAb IgM and IgG
      1. Low Infectivity
      2. Predicts Hepatitis B Resolution
  4. Course of serology progression
    1. Stage 1: Immune Tolerant or Incubation Period
      1. Characteristics
        1. DNA replication very active in this stage
        2. Prolonged stage in newborns
        3. Asymptomatic (Serum Aminotransferases normal)
      2. Incubation (4-12 weeks)
      3. Late incubation (1-2 weeks)
        1. HBsAg Positive
    2. Stage 2: Immune Response
      1. Characteristics
        1. Immune response causes hepatic cell destruction
          1. Serum Aminotransferases increased
        2. High risk stage for Chronic Hepatitis B progression
        3. Symptom flares may occur if immunocompromised
        4. Conversion to Stage 3
          1. Occurs in most adults rapidly
          2. Others convert 5-15% per year
      2. Early Acute
        1. HBsAg Positive
        2. HBeAg Positive
      3. Acute (2-12 weeks)
        1. HBsAg Positive
        2. HBeAg Positive
        3. xHBc IgM Antibody Positive
        4. xHBc IgG Antibody Positive
      4. Acute and Seroconversion (transitions into Stage 3)
        1. HBsAg Positive
        2. xHBc IgM Antibody Positive
        3. xHBc IgG Antibody Positive
        4. xHBe IgG Antibody Positive
    3. Stage 3: Inactive carrier state (3-6 months)
      1. Characteristics
        1. Viral replication stops and transaminases normalize
        2. Possibly infectious and convalescent stage
        3. Conversion to Stage 4: 3% per year
      2. HBsAg Negative
      3. xHBc IgM Antibody Positive
      4. xHBc IgG Antibody Positive
      5. xHBe IgG Antibody Positive
    4. Stage 4: Immune and Early Recovery
      1. xHBc IgG Antibody Positive
      2. xHBe IgG Antibody Positive
      3. xHBs IgG Antibody Positive
  5. Resources
    1. CDC NCI Viral Hepatitis B
      1. http://www.cdc.gov/ncidod/diseases/hepatitis/b
  6. References
    1. Murray (1999) Clin Microbiol Rev 12:351

Hepatitis B e Antigens (C0019167)

Definition (MSH)A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.
ConceptsImmunologic Factor (T129)
MSHD006513
Englishe Antigens, Hbe Ag, HBeAg, Hepatitis B associated e antigen, HEPATITIS B E ANTIGEN, Hepatitis B e Antigens, HEPATITIS B VIRUS e AG, Hepatitis B virus e Antigen, Hepatitis B virus little e Ag, Hepatitis Be Antigens, Hepatitis E antigen
Spanishantigeno e asociado con la hepatitis B, antigeno e de la hepatitis, antigeno e de la hepatitis B
Parent ConceptsHepatitis B Antigens (C0019165)
SourcesDXP, LNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Hepatitis B Surface Antigens (C0019168)

Definition (MSH)Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Definition (AIR)Hepatitis B Surface Antigen: a viral antigen of the hepatitis B virus detected by radioimmunoassay.
Definition (NCI)Any one of the hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
ConceptsPharmacologic Substance (T121) , Immunologic Factor (T129)
MSHD006514
EnglishAustralia antigen, Australian antigen, Hb s Ag, Hb<sub>s</sub> Ag, Hb>s< Ag, HBsAg, Hepatitis associated antigen, Hepatitis B Surface Antigen, HEPATITIS B SURFACE ANTIGEN PREPARATION, Hepatitis B Surface Antigens, Hepatitis B virus surface Ag, Hepatitis B virus surface antigen, Hepatitis surface antigen
Spanishantigeno australiano, antigeno de superficie de la hepatitis, antigeno de superficie de la hepatitis B
Parent ConceptsLaboratory: serologic tests for bacteriae or viruses (C0151342), Lab Findings: Serologic Tests for Bacteriae, Viruses (C0221584), Hepatitis B Antigens (C0019165), Antigens (C0003320), HEPATITIS B [Ingredient] (C1372982)
SourcesAIR, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, OMIM, QMR, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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