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Hepatitis B VaccineAka: Hep B Vaccine
- Indications
- All Newborns (at birth, age 2 months, and age 6 months)
- All health care personnel
- Hemodialysis patients
- Patients requiring frequent blood transfusion
- Staff and residents at developmentally disabled home
- Male homosexuals and their sexual contacts
- Intravenous Drug Abuse
- Sexual contacts of chronic HBsAg carriers
- Consider for areas of high prevelance
- Asia
- Sub-Saharan Africa
- Contraindications
- Anaphylactic reaction to baker's yeast
- Efficacy
- Starting series after age 3 months may improve immunity
- Immunity appears to be lifelong after series
- References
- Available Preparations
- Recombivax HB
- Infants, Children and Adolescents: 5 ug/dose
- Adults: 10 ug/dose
- Immunosuppressed Adult: 20 ug/dose
- Energix-B (SKB)
- Infants and Children: 10 ug/dose
- Twinrix (Combined Hepatitis A and Hepatitis B Vaccine)
- Adults: 720 EU/20 ug (1.0 ml)
- Not approved for use in Children
- Requires 3 doses as in Hepatitis B Vaccine schedule
- Recombivax HB
- Dosage: Protocols for Standard Schedule (Harmonized Schedule)
- Dose 1: Birth to age 2 months (first dose at age >1 month if birth weight <2000 grams)
- Dose 2: Age 1 to 4 months (>1 month after dose 1)
- Dose 3: Age 6 to 18 months (>2 months after dose 2)
- Alternative Protocols
- Rapid Vaccination (3 weeks) French Study
- French Protocol
- Regular: Days 0, 28, and 56
- Rapid: Days 0, 10, and 21
- Efficacy compared with regular French schedule
- Day 28: Higher seroprotection than reg schedule
- Day 56: Lower seroprotection than regular
- Day 365: Same seroprotection as regular schedule
- References
- French Protocol
- Moderately Rapid Vaccination schedule
- Rapid Schedule: months 0, 1, and 2
- Efficacy
- Month 3: Greater seroprotective effect
- Month 7: Equivalent seroprotection (100%)
- Higher Antibody titer for standard group
- Suggests possible longer term protection
- References
- Rapid Vaccination (3 weeks) French Study
- Management: Infant with HBsAg Positive Mother
- Administer HBig and Hepatitis B Vaccine
- Hepatitis B Immunoglobulin (HBIG)
- Dose: 0.5 ml within 12 hours of birth
- Hepatitis B Vaccine starting with dose in hospital
- Dose 1: Within 12 hours of birth
- Dose 2: Age 1 months
- Dose 3: Age 6 months
- Additional Dose: Age 2 months if birth weight <2000 grams
- Hepatitis B Immunoglobulin (HBIG)
- Labs at 9 and 15 months of age
- Administer HBig and Hepatitis B Vaccine
- Precautions
- Safe in HIV
- Safe in Pregnancy
- Adverse Effects
- One reaction per 600,000 doses
- References
- References
Hepatitis B Vaccine (C0062527) | |
|---|---|
| Definition (MSH) | Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced. |
| Definition (PDQ) | A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=532310&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=532310&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29091" NCI Thesaurus) |
| Definition (NCI) | A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. (NCI04) |
| Definition (HL7V3.0) | hepatitis B vaccine, NOS |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| MSH | D017325 |
| English | HBIG - Hepatitis B vaccine, Hep B - Hepatitis B vaccine, HEPATITIS B, Hepatitis B Vaccine, HEPATITIS B VACCINE PREPARATION, Hepatitis B Vaccines, Hepatitis B virus vaccine, Hepatitis B virus vaccine inactivated |
| Spanish | vacuna contra el virus de la hepatitis B, vacuna inactivada anti-hepatitis B |
| Parent Concepts | Vaccines administered (code = CVX)(parenteral, unless oral is noted) (C1547693), VaccineType (C1554000), Viral Hepatitis Vaccines (C0042723), recombinant viral vaccine (C0281606), Vaccines (C0042210), Unclassified Ingredients (C1372954), Viral Vaccines (C0042742) |
| Sources | HL7V2.5, HL7V3.0, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
