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Leukemia
Aka: Leukemia- Epidemiology
- Types
- Myeloid Leukemia (Bone Marrow)
- Lymphoid Leukemia
- Acute Lymphocytic Leukemia (ALL)
- Chronic Lymphocytic Leukemia (CLL)
- Hairy-Cell Leukemia
- Pathophysiology
- Malignant neoplasm of hematopoietic origin
- Origins
- Myeloid (Bone Marrow)
- Lymphoid
- Acute (Proliferating cell fails to mature past blast)
- AML: Immature clonal myeloid Cells (Myeloblast)
- ALL: Immature clonal lymphoid Cells (Lymphoblast)
- Predisposing Factors
- Idiopathic
- Human T-Cell Leukemia Virus (HTLV-1)
- Congenital syndrome
- Down's Syndrome
- Bloom's Syndrome
- Klinefelter's Syndrome
- Fanconi's Syndrome
- Wiskott-Aldrich Syndrome
- Environmental Factors
- Ionizing Radiation exposure (risk of CML, AML, ALL)
- Chemical exposure (risk of AML)
- Aromatic hydrocarbons (e.g. Benzene)
- Alkylating Agents
- Chemotherapeutic drugs