Infectious Disease Book

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NitrofurantoinAka: Macrodantin, Macrobid, Furadantin

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  1. Indications
    1. Urinary Tract Infection
  2. Preparations
    1. Macrobid
      1. Capsules: 100 mg
    2. Nitrofurantoin
      1. Capsules: 25 mg, 50 mg, 100 mg
      2. Suspension: 25 mg per 5 ml
  3. Directions
    1. Take immediately after food to increase absorption
    2. Food decreases gastrointestinal upset
  4. Dosing: Adults
    1. Nitrofurantoin: 50 to 100 mg PO qid
    2. Macrobid: 100 mg PO bid
    3. Course: 5 days (instead of 7) is sufficient for uncomplicated UTI in non-pregnant women
      1. Gupta (2007) Arch Intern Med 167(20):2207
  5. Dosing: Children
    1. Nitrofurantoin: 5-7 mg/kg/day divided qid

Nitrofurantoin (C0028156)

Definition (MSH)A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.
Definition (NCI)A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD009582
EnglishNitrofurantoin, NITROFURANTOIN PREPARATION
Spanishnitrofurantoina
Parent ConceptsNitrofurans (C0028155), Anti-Infective Agents, Urinary (C0003207), [AM600] NITROFURANS ANTIMICROBIALS (C0973483), Nitrofuran derivative (C0770668), Nitrofuran Antibacterials (C1579349)
SourcesAOD, CSP, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Macrobid (C0591750)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishMacrobid
SourcesMTH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Macrodantin (C0700187)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD009582
EnglishMacrodantin
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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