Infectious Disease Book

http://www.fpnotebook.com/

Nitrofurantoin

Aka: Nitrofurantoin, Macrodantin, Macrobid, Furadantin
  1. Indications
    1. Urinary Tract Infection
  2. Contraindications
    1. Creatinine Clearance <60 ml/minute
  3. Adverse Effects
    1. Pulmonary fibrosis
  4. Preparations
    1. Macrobid
      1. Capsules: 100 mg
    2. Nitrofurantoin
      1. Capsules: 25 mg, 50 mg, 100 mg
      2. Suspension: 25 mg per 5 ml
  5. Directions
    1. Take immediately after food to increase absorption
    2. Food decreases gastrointestinal upset
  6. Dosing: Adults
    1. Nitrofurantoin: 50 to 100 mg PO qid
    2. Macrobid: 100 mg PO bid
    3. Course: 5 days (instead of 7) is sufficient for uncomplicated UTI in non-pregnant women
      1. Gupta (2007) Arch Intern Med 167(20):2207-12
  7. Dosing: Children
    1. Nitrofurantoin: 5-7 mg/kg/day divided qid

Macrobid (C0591750)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Macrobid, macrobid, macrobids
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Macrodantin (C0700187)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009582
English macrodantin, Macrodantin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nitrofurantoin (C0028156)

Definition (MSH) A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.
Definition (NCI) A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009582
SnomedCT 373543005, 85343003
English Nitrofurantoin, 2,4-Imidazolidinedione, 1-(((5-nitro-2-furanyl)methylene)amino)-, nitrofurantoin, nitrofurantoin (medication), urological antibacterial nitrofurantoin, Nitrofurantoin [Chemical/Ingredient], NITROFURANTOIN, Nitrofurantoin (product), Nitrofurantoin (substance)
Swedish Nitrofurantoin
Czech nitrofurantoin
Finnish Nitrofurantoiini
Russian NITROFURANTOIN, FURADONIN, НИТРОФУРАНТОИН, ФУРАДОНИН
Japanese ニトロフラントイン
Croatian NITROFURANTOIN
Spanish Nitrofurantoína, Nitrofurantoina, nitrofurantoína (producto), nitrofurantoína (sustancia), nitrofurantoína
Polish Furadantyna, Nitrofurantoina
French Nitrofurantoïne
German Nitrofurantoin
Italian Nitrofurantoina
Portuguese Nitrofurantoína
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree