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Uric Acid

Physiology
1. Uric acid is a metabolic-by-product of purine catabolism
2. Uricase converts uric acid to allantoin in most mammals, but is dysfunctional in humans
3. Uric acid varies considerably with purine and Alcohol intake, as well as Renal Function
Normal
1. Uric acid: 2-7 mg/dl
Increased (Hyperuricemia)
1. See Hyperuricemia
Decreased
1. Drugs
  1. Allopurinol
  2. High dose ASA
  3. Probenecid
  4. Coumadin
  5. Corticosteroids
2. SIADH
3. Renal tubule disease (Fanconi Syndrome)
4. Liver disease
5. Alcohol
6. Wilson's Disease
7. Hemochromatosis
8. Protein or purine deficient diet
9. Xanthine-oxidase deficiency

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.