II. Pathophysiology

  1. Drugs are second most common cause of Neutropenia
  2. Induce hypoproliferation via marrow injury

III. Causes: Most common

  1. Chemotherapeutics (standard effect)
  2. Thyroid inhibitors (Antithyroid Drugs)
  3. Trimethoprim-Sulfamethoxazole (Septra, Bactrim)
  4. Sulfasalazine
  5. Clomipramine
  6. Dipyrone
  7. Concurrent Analgesic use is predisposing factor

IV. Causes: Chemotherapeutics (most common causes)

VI. Causes: Neuropsychotropics

  1. Phenothiazine (e.g. chlorpromazine)
  2. Meprobamate
  3. Barbiturates
  4. Clozapine (Clozaril)
  5. Risperidone (Risperdal)
  6. Imipramine or Desipramine
  7. Thiothixene (Navane)
  8. Haloperidol (Haldol)
  9. Valproic Acid (Depakote)
  10. Phenytoin (Dilantin)
  11. Carbamazepine (Tegretol)
  12. Ethosuximide (Zarontin)

VIII. Causes: Analgesics

IX. Causes: Miscellaneous

  1. Allopurinol
  2. Colchicine
  3. Antithyroid Drugs (e.g. Propylthiouracil)
  4. Antihistamines (e.g. Cimetidine, Brompheniramine)
  5. Quinine
  6. Heavy Metals
    1. Gold
    2. Arsenic
    3. Mercury

X. References

  1. Lee (1999) Wintrobe's Hematology, Lippincott, p. 1862-9
  2. van der Klauw (1999) Arch Intern Med 159(4):369-74 [PubMed]

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