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ValproateAka: Valproic Acid, Depakote, Depakene

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  1. Indications
    1. Generalized Tonic Clonic Seizures
    2. Absence Seizures
    3. Myoclonic Seizures
    4. Simple Partial Seizures
    5. Complex Partial Seizures
    6. Migraine Headache Prophylaxis
    7. Mania
  2. Contraindications
    1. Hepatic dysfunction
    2. Pregnancy
    3. Urea cycle disorder
  3. Adverse Effects: Dose related
    1. Nausea and Vomiting
    2. Tremor
    3. Ataxia
    4. Diarrhea
    5. Lethargy
    6. Mild Liver Function Test abnormalities (AST, ALT)
  4. Adverse Effects
    1. Pancreatitis
    2. Alopecia
      1. Centrum A-Zinc daily prevents associated Hair Loss
    3. Thrombocytopenia
    4. Stevens-Johnson Syndrome
    5. Osteoporosis
    6. Hepatic dysfunction (in rare cases, may be fatal)
  5. Dosing: Adults
    1. Seizure Disorder
      1. Initial: 10-15 mg/kg/day divided qd - tid
      2. Increase in 5-10 mg/kg/day increments weekly
      3. Target dose: 30-60 mg/kg/day to 1000-2500 mg/day
        1. Divide regular and delayed release dosing bid-qid
        2. Extended release may be dosed once daily
    2. Migraine Headache Prophylaxis
      1. Initial
        1. Depakote ER 500 mg PO qd for 7 days
        2. Depakote delayed release 250 mg PO bid
      2. May increase to 1000 mg/day
  6. Drug Interactions
    1. Numerous drug interactions
  7. Toxicity
    1. Large therapeutic Window
  8. Monitoring
    1. Plasma level correlates with clinical response
    2. Follow Liver Function Tests
  9. Pregnancy Risk
    1. Class D

Valproate (C0080356)

Definition (CSP)fatty acid with anticonvulsant properties.
ConceptsLipid (T119) , Pharmacologic Substance (T121)
English2 propylvalerate, Valproate, VALPROATE PREPARATION, Valproate product
Spanishvalproato
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Depakene (C0700661)

ConceptsLipid (T119) , Pharmacologic Substance (T121)
EnglishDepakene, Depakine
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Depakote (C0719751)

ConceptsLipid (T119) , Pharmacologic Substance (T121)
EnglishDepakote
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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