I. Class

  1. Propanediol Sedative

II. Indications

  1. Anxiety

III. Pharmacokinetics

  1. Half Life: 6-17h

IV. Dosing

  1. Max Daily Dose: 1600 mg qd

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Cost: Medications

meprobamate (on 6/17/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
MEPROBAMATE 200 MG TABLET Generic $1.43 each
MEPROBAMATE 400 MG TABLET Generic $2.58 each

Ontology: Meprobamate (C0025386)

Definition (NCI) A carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system.
Definition (MSH) A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008620
SnomedCT 387395007, 70864001
LNC LP16187-4, MTHU011050
English Meprobamate, 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate, 1,3-Propanediol, 2-methyl-2-propyl-, Dicarbamate, Miltown 600, Neuramate, meprobamate (medication), meprobamate, MEPROBAMATE, Meprobamate [Chemical/Ingredient], Meprobamate (product), Meprobamate (substance)
Swedish Meprobamat
Czech meprobamát
Finnish Meprobamaatti
Japanese メプロバメート
Polish Meprobamat, Miltown, Equanil
Spanish Equanil, meprobamato (producto), meprobamato (sustancia), meprobamato, Meprobamato
Portuguese Equanil, Meprobamato
French Méprobamate
German Meprobamat
Italian Meprobamato

Ontology: Equanil (C0591455)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008620
English equanil, Equanil, Meprobamate Wyeth Brand, Sanofi Synthelabo Brand of Meprobamate, Wyeth Brand of Meprobamate