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MeprobamateAka: Equanil
- Class
- Propanediol Sedative
- Indications
- Anxiety
- Pharmacokinetics
- Half Life: 6-17h
- Dosing
- Max Daily Dose: 1600 mg qd
Meprobamate (C0025386) | |
|---|---|
| Definition (MSH) | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) |
| Definition (NCI) | A carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008620 |
| English | Meprobamate, MEPROBAMATE PREPARATION, Miltown 600, Neuramate |
| Spanish | meprobamato |
| Parent Concepts | Carbamates (C0006948), Anticonvulsants (C0003286), [CN309] SEDATIVES/HYPNOTICS, OTHER (C0993165), Carbamate sedative (C0360124), Anxiolytics, Other (C1579425) |
| Sources | AOD, CSP, LNC, MSH, MTH, MTHFDA, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Equanil (C0591455) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008620 |
| English | Equanil, Meprobamate Wyeth Brand, Sanofi Synthelabo Brand of Meprobamate, Wyeth Brand of Meprobamate |
| Sources | MSH, NCI, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
