III. Mechanisms

  1. Drug-absorption or hapten-induced
    1. Medication coats Red Blood Cell surface
    2. Induces IgG Antibody production
  2. Immune-complex
    1. Drug stimulates IgM production and binding
    2. Drug-IgM complex binds RBC and complement induced
  3. Autoantibody
    1. Drug stimulates IgG production against RBC membrane

IV. Causes: Positive Anti-IgG (Extravascular Hemolysis)

V. Causes: Positive Anti-C3 (Intravascular Hemolysis)

  1. Acetaminophen
  2. Chlorpromazine
  3. Fluorouracil
  4. Hydrochlorothiazide
  5. Hydralazine
  6. Insulin
  7. Isoniazid
  8. Melphalan
  9. Phenacetin
  10. Probenacid
  11. Quinidine
  12. Quinine
  13. Rifampin
  14. Streptomycin
  15. Sulfonamides
  16. Sulindac
  17. Tetracycline

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