Rheumatology Book

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AdalimumabAka: Humira

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  1. See Also
    1. Etanercept (Enbrel)
    2. Infliximab (Remicade)
  2. Indications
    1. Severe active Rheumatoid Arthritis refractory to DMARDs
  3. Contraindications
    1. Chronic or acute infection
    2. Concurrent use of Interleukin-1 Receptor Antagonist
      1. Anakinra (Kineret)
  4. Mechanism: Monoclonal Antibody
    1. Human antitumor Necrosis Factor alpha
    2. Similar to Infliximab and Etanercept
  5. Dosing
    1. Every other week: 40 mg SC
  6. Adverse Effects
    1. Immunosuppression
      1. Use caution in any patient prone to infection
    2. Headache
    3. Rash
    4. Hypertension
    5. Hyperlipidemia
    6. Injection site inflammation
    7. Gastrointestinal upset
  7. Cost
    1. Two 40 mg vials: $1200 (in 2003)
  8. References
    1. (2003) Lexi-Comp Drug Database

adalimumab (C1122087)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSHC453439
Englishadalimumab, ADALIMUMAB PREPARATION, D2E7 antibody
Spanishadalimumab
Parent ConceptsImmunosuppressive Agents (C0021081), Other antirheumatics (C0973578), Unclassified Ingredients (C1372954), Antirheumatic Agents (C0003191), Monoclonal antibody preparation (C1298636), Anti-tumor necrosis factor alpha drug (C1562242), Tumor Necrosis Factor (TNF) Inhibitors (C1579324)
SourcesMSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Humira (C1171255)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSHC453439
EnglishAbbott brand of adalimumab, Humira
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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