Rheumatology Book

http://www.fpnotebook.com/

Etanercept

Aka: Etanercept, Enbrel
Advertisement
  1. See Also
    1. Infliximab (Remicade)
    2. Adalimumab (Humira)
  2. Indication
    1. Refractory Rheumatoid Arthritis
      1. Combined with Methotrexate and other DMARDs
      2. Corticosteroid sparing in agents
    2. Juvenile Rheumatoid Arthritis
    3. Psoriatic Arthritis
  3. Mechanism
    1. Soluble TNF receptor blocker
  4. Efficacy
    1. Rapid onset and very effective
    2. Arrests XRay progression
    3. Good synergistic effect with Methotrexate
  5. Adverse Effects
    1. Potential risk of infection
    2. No significant adverse effects
  6. Dosing
    1. Preloaded vial or syringe: 25 mg SQ twice weekly or 50 mg SC weekly
  7. Cost
    1. Per vial: $150
    2. Per month: $1200
    3. Per year: $14,000
  8. Monitoring
    1. Consider following Complete Blood Count
  9. References
    1. Bathon (2000) N Engl J Med 343:1586-93
    2. Weinblatt (1999) N Engl J Med 340: 253-9
Medication Costs
Enbrel (on 2/9/2012 at DrugStore.com)
Enbrel 4 25mg Kit (1 Box = 1 Kit = Four 25mg Vials) #1 for $979.01 ($979.01/unit)
Enbrel 50mg/ml Solution (1 Box = 1 Kit = Four 50mg Syringes) #1 for $1902.99 ($1902.99/unit)
Enbrel 25mg/0.5ml Solution 0.51ml Syringe #1 for $260.99 ($260.99/unit)
Enbrel SureClick (on 2/9/2012 at DrugStore.com)
Enbrel SureClick 50mg/ml Solution (1 Box Contains Four 50mg Prefilled Autoinjectors) #1 for $1910.02 ($1910.02/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Enbrel (C0720193)

Definition (CHV) brand name of a drug that is used to treat rheumatism
Definition (CHV) brand name of a drug that is used to treat rheumatism
Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH C106167
English Enbrel, etanercept (Enbrel), enbrel [brand name], enbrel, Immunex brand of etanercept, Wyeth brand of etanercept
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Etanercept (C0717758)

Definition (NCI) A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.
Definition (NCI) A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
Definition (PDQ) A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2381" NCI Thesaurus)
Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH C106167
SnomedCT 118259007, 387045004
English Tumor Necrosis Factor Receptor IgG Chimera, tumor necrosis factor receptor IgG chimera, etanercept (medication), ETANERCEPT, Etanercept, Etanercept (product), Etanercept (substance), TNFR:Fc, etanercept, ETN
Spanish etanercept (producto), etanercept (sustancia), etanercept
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree