Infectious Disease Book

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TetracyclineAka: Doxycycline, Minocycline

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  1. Dosing: Acne Vulgaris
    1. Tetracycline 1g/d given in 2-4 divided doses
    2. Doxycycline 100-200 mg/day in divided doses
    3. Minocycline 50-200 mg/d in divided doses
  2. Directions
    1. Tetracycline
      1. Milk and food decrease absorption
      2. Take 1 hour before or 2 hours after a meal
    2. Doxycycline and Minocycline
      1. Can be taken with food (unlike Tetracycline)
  3. Adverse Effects
    1. Tetracycline
      1. Photosensitivity
      2. Interferes with OCP action
    2. Doxycycline
      1. Photosensitivity
    3. Minocycline
      1. Generally well tolerated
      2. Does not generally cause photosensitivity
      3. Rare adverse effects
        1. Lupus-like syndrome (1:20,000)
        2. Vertigo
        3. Oral Mucosa pigmentation (blue-black pigmentation)
        4. Hypersensitivity Syndrome within 1-3 months
        5. Delayed arthralgias or Polyarthritis
  4. Disadvantages
    1. Minocycline is very expensive ($1 to $2/pill)

Doxycycline (C0013090)

Definition (MSH)A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
Definition (NCI)An antibiotic drug used to treat infection.
Definition (PDQ)A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C457" NCI Thesaurus)
Definition (NCI)A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
Englishalpha 6 Deoxyoxytetracycline, Doxycycline, DOXYCYCLINE PREPARATION
Spanishdoxiciclina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Minocycline (C0026187)

Definition (MSH)A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishMinocycline, MINOCYCLINE PREPARATION
Spanishminociclina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Tetracycline (C0039644)

Definition (MSH)A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Definition (NCI)A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishTCN, TETRA, Tetracycline, TETRACYCLINE PREPARATION
Spanishtetraciclina
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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