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Malaria ChemoprophylaxisAka: Malaria Prophylaxis
- See Also
- Malaria
- Prevention of Vector-borne Infection
- General
- Always check CDC for resistance before prescribing
- CDC Travelers Health for regional recommendations
- http://www.cdc.gov/travel
- Chemoprophylaxis is for prevention only
- Dosing below does not apply to Malaria treatment
- Chemoprophylaxis Schedule
- Agents are started 1-2 weeks before travel
- Agents are continued for 4 weeks after travel
- Chemoprophylaxis: First Line
- Indications (Areas of no Chloroquine Resistance)
- Mexico
- Caribbean
- Central America
- Argentina
- Some areas in Middle East
- Some areas of China
- Chloroquine (Aralen)
- Adult: 500 mg (300 mg base) PO weekly
- Child: 8.3 mg/kg (5 mg/kg of base) PO weekly
- Chemoprophylaxis: 2nd Line (if No Mefloquine resistance)
- Indications
- Chloroquine resistance
- Safe in pregnancy
- Contraindications (relative)
- Seizure disorder
- Cardiac conduction abnormality
- Psychosis
- Mefloquine (Lariam)
- Adult: 250 mg (228 mg base) PO weekly
- Child: See Mefloquine for pediatric dosing
- Chemoprophylaxis: Third Line
- Indications
- Short term travel to Chloroquine resistance areas
- Mefloquine resistance areas
- Thailand - Cambodia border
- Thailand - Myanmar (Burma) border
- Contraindications
- Lactating women
- Children under age 8 years
- Doxycycline (Vibramycin)
- Adult Dosing: 100 mg PO qd
- Pediatric Dosing (may use if older than age 8)
- Dose: 2 mg/kg/day up to 100 mg qd
- Chemoprophylaxis: Terminal prophylaxis
- Indications (on leaving endemic area)
- Prolonged exposure to P. vivax or P. ovale
- Taken for 14 days on leaving endemic area
- Contraindications
- Pregnancy
- G6PD Deficiency
- Adult dose
- Primaquine 26.3 mg PO qd for 14 days
- Chemoprophylaxis: Other agents (adult dosing)
- Atovaquone/Proguanil (Malarone) 250/100 mg PO qd
- Azithromycin (Zithromax) 250 mg PO qd
- Tafenoquine (Etaquine) 250 mg PO weekly
- Pyrimethamine with sulfadoxine (Fansidar)
- References
- Gilbert (2001) Sanford Guide, p. 88
- Kain (2001) Clin Infect Dis 33:226
- Lo Re (2003) Am Fam Physician 68(3):509
Antimalarial prophylaxis (C0199244)
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| Concepts | Therapeutic or Preventive Procedure (T061)
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| English | Antimalarial drug prophylaxis, Antimalarial prophylaxis, Malaria prophylaxis, Malarial prophylaxis |
| Spanish | prescripción de un agente profiláctico antipalúdico, prescripcion de un agente profilactico antipaludico, profilaxis antipalúdica, profilaxis antipaludica, profilaxis contra la malaria, profilaxis farmacológica antipalúdica, profilaxis farmacologica antipaludica |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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